Hair Growth and Disorders

Topically applied thyroid hormones stimulate hair growth in organ-cultured human scalp skin

This study shows that topical thyroid hormones T3 and T4 promote hair growth in human scalp skin ex vivo by increasing anagen phase, reducing cell proliferation, and enhancing angiogenesis and growth factor expression.

Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

The paper shows that Meis2 in neural crest-derived mesenchymal cells is essential for whisker development, independent of trigeminal innervation or Foxd1.

Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men

This study identifies genetic associations and evolutionary factors underlying androgenetic alopecia in African men, showing poor generalization of European genetic predictions and continental differences in allele frequencies.

Rhamnose-mediated modulation of hair follicle growth: insights from chemical genomics

This study identifies rhamnose as a compound that promotes hair follicle growth by restoring hair-inducing gene expression and inducing glucose metabolism remodeling.

Defining epithelial stem cell heterogeneity through undulating structures of the skin and oral mucosa

This study investigates how undulating tissue structures influence epithelial stem cell heterogeneity in skin and oral mucosa using mouse models and 3D culture systems.

Experimental method for creating skin with acquired appendage dysfunction

This study develops two mouse models with acquired skin appendage dysfunction to study regeneration, showing that thin grafts produce skin with minimal appendages.

Differential Expression of Edar and Xedar During Mouse and Rat Tail Appendage Development

The paper quantifies Edar and Xedar expression in mouse and rat tail appendages during development, revealing species-specific expression patterns linked to hair versus scale formation.

Genetic Characterization of the Cell Types of in Developing Feathers, and the Evolution of Feather Complexity

The paper characterizes feather cell types in developing chicken embryos using single-cell RNA sequencing and identifies a new cell type, while analyzing their evolutionary relationships.

Differential expression of keratin and keratin associated proteins are linked with hair loss condition in spontaneously mutated inbred mice

The paper identifies differentially expressed keratin and keratin-associated proteins in mutant mice with hair loss, linking them to hair follicle formation defects.

New technologies for hair follicle growth and regeneration: comparison between different commercial products contain exosomes

The paper compares two exosome-based products for hair follicle regeneration, finding that bovine colostrum-derived exosomes promote dermal papilla growth better than umbilical cord stem cell-derived exosomes.

Nitrate Promoting Hair Growth Through Enhancing Wnt/β-catenin and Downregulating TGF-β/Samd/BMP signaling pathway in C57BL/6 Mice

This study shows nitrate promotes hair growth in mice by enhancing Wnt/β-catenin signaling and reducing TGF-β1/Smad/BMP pathway activity.

ARHGEF3 Regulates Hair Follicle Morphogenesis

This study identifies ARHGEF3 as a regulator of hair follicle morphogenesis by promoting cell shape rearrangements during placode formation in mice.

Wound-initiated hair regeneration by adhesive and shrinkable materials

This study shows that inducing epidermal regeneration through adhesive and shrinkable materials can trigger hair follicle neogenesis in mice, regardless of age or sex, leading to synchronized hair growth.

Hair follicles modulate skin barrier function

This study identifies four mechanisms by which hair follicles modulate skin barrier function using genetic ablation of Abca12 in upper hair follicles.

Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis

This study identifies CerS4's role in regulating hair follicle stem cell niche formation through sphingolipid metabolism, impacting skin homeostasis and barrier function.

Wnt target gene Ascl4 is dispensable for skin appendage development

This study shows that Ascl4, a Wnt/{beta}-catenin target gene, is not essential for skin appendage development in mice.

Mesenchyme governs hair follicle induction

This study identifies that mesenchyme can induce hair follicles before dermal condensate formation in mouse embryos.

Col4a2-eGFP mouse model reveals the molecular and functional dynamics of basement membrane remodelling in hair follicle morphogenesis

The study uses a fluorescent mouse model to show that basement membrane dynamics during hair follicle development are spatially graded and influence progenitor cell behavior and organ shape.

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

This study creates a prenatal human skin cell atlas, revealing immune cells' role in skin development and showing their impact on vascular and hair follicle formation.

Neurotransmitter signaling specifies sweat gland stem cell fate through SLN-mediated intracellular calcium regulation

This study shows that neurotransmitter signaling via SLN-mediated calcium regulation determines sweat gland stem cell fate during development.

Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury

This study identifies distinct mechanisms for sebaceous gland self-renewal and regeneration, showing that injury triggers replacement by hair follicle-derived stem cells and FGFR-dependent regeneration.

Region-specific reversal of epidermal planar polarity in the fancy rosette mouse

The paper studies epidermal planar polarity reversal in the fancy rosette mouse, finding a region-specific rotation of the PCP axis due to a mutation in Fzd6.

Transcriptomic landscape of early hair follicle and epidermal development

The paper uses bulk and single-cell transcriptomics to study early hair follicle and epidermal development, identifying new cell populations and markers.

MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells

This study shows that miR-205 modulates the mechanical properties of hair follicle stem cells and progenitors to promote hair regeneration.

A transient dermal niche and dual epidermal programs underlie sweat gland development

This study identifies two epidermal transcriptomes and a transient dermal niche in eccrine gland development using single nucleus transcriptomics in mice.

Lineage Commitment of Dermal Fibroblast Progenitors is Mediated by Chromatin De-repression

This study identifies the role of chromatin de-repression mediated by Kdm6b/Jmjd3 in lineage commitment of dermal fibroblast progenitors during skin development.

New insights on the genetics of hair whorls from twins and the Southern hemisphere

The paper investigates the genetic and environmental influences on hair whorl formation using twin data and hemispheric comparisons.

Molecular and spatial design of early skin development

This study uses single-cell transcriptomics and spatial analysis to map early mouse skin development, revealing new cell types and interactions.

The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging

This study shows that fibulin 7 maintains epidermal stem cell heterogeneity during skin aging by preserving fast-cycling clones and preventing inflammation-related gene expression.

Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease

The paper integrates single-cell chromatin and transcriptomic data from human scalp to identify gene regulatory mechanisms and causal variants in hair and skin diseases.