Hair-bearing human skin generated entirely from pluripotent stem cells
Jiyoon Lee, Cyrus C. Rabbani, Hongyu Gao, Matthew R. Steinhart, Benjamin M. Woodruff, Zachary E. Pflum, Alexander Kim, Stefan Heller, Yunlong Liu, Taha Z. Shipchandler, Karl R. Koehler
Stepwise modulation of TGFβ, BMP, and FGF signaling in human pluripotent stem cell aggregates generates innervated, pigmented hair-bearing skin organoids that form planar human skin when grafted onto nude mice.
Nature · Jun 3, 2020Peer-reviewedDevelopmental Biology✦ In-depth digest