Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology

Receptor Mechanisms and Signaling

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

Pharmacology & Toxicology·Journal of Biological ChemistryPeer-reviewed·Aug 19, 2025
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Increased RAMP3 expression enhances GLP-1 mediated Glucose Stimulated Insulin Secretion in a Manner Dependent on Ca2+ Mobilisation
Abigail Pearce, Poonam Kumari, Claudia M. Sisk…+4 more authors·Graham Ladds
RAMP3 complexes with GLP-1R at the plasma membrane, shifts signalling toward Ca2+ mobilisation, and enhances insulin secretion in INS-1 832/3 cells; Ramp3 loss blunts GLP-1 responses in mice.
8 citations
mouse·rat
Bioengineering·Journal of Molecular BiologyPeer-reviewed·Apr 21, 2025
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GPCRchimeraDB: A database of chimeric G protein-coupled receptors (GPCRs) to assist their design
Charlotte Crauwels, Adrián Díaz, Wim Vranken
Resource of 212 literature-curated chimeric class A GPCRs linked to 1,755 natural class A mammalian GPCRs, annotated at sequence, structure and biophysics level, with guidelines for designing new chimeras.
2 citations
multiple species·protein sequence