Clinical Laboratory Practices and Quality Control

Development, validation and clinical implementation of cellular swab materials for quality assurance of pharmacogenomic point-of-care testing

The paper develops and validates cell-based swab materials for pharmacogenomic point-of-care testing, demonstrating their effectiveness in quality assurance and external quality assessment.

Sex and race shape serum protein biomarkers and bias diagnostic reference intervals

The paper quantifies protein biomarkers across diverse demographics and shows sex and race influence reference intervals, leading to potential misclassification.

FlowSpot Enables Decentralized Phenotypic and Functional Cellular Immune Profiling from Dried Blood Spots

FlowSpot enables robust flow cytometric analysis of immune cells from dried blood spots, preserving immunophenotypic and functional characteristics for decentralized clinical applications.

Improving Turnaround Times with Artificial Intelligence in Microbiology

This study shows that AI software reduces urine culture turnaround times in microbiology labs, with significant improvements in both low- and high-volume settings.

Distance-to-optimum biological drift as a new framework for interpreting routine laboratory results: a benchmark against Reference Change Values across 62 routine biomarkers

The paper benchmarks a new biological drift framework against Reference Change Values (RCVs) for 62 routine biomarkers, showing severe drifts often exceed RCV thresholds, suggesting meaningful deviations from individual optima.

Characterization of pre-analytical blood collection and stabilization parameters to maintain endogenous protein levels for remote blood sampling technology

The paper optimizes pre-analytical blood collection and stabilization parameters to maintain protein integrity for remote blood sampling, finding that Protein Plus stabilizer effectively limits hemolysis and protein degradation.

Blood draw site and blood matrix influence mineral assessment

This study examines how blood draw site and matrix affect mineral concentrations in samples, finding significant variations in calcium, copper, iron, and magnesium levels between capillary/venous and plasma/serum samples.

Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays

This study compares five NfL immunoassays in plasma and CSF, finding four with excellent performance and noting assay-specific biases and correlations.

EDTA tubes are suitable for insulin and C-peptide measurement in resource-limited settings and can be stored at room temperature for up to 24 hours

This study shows that K2EDTA tubes allow stable insulin and C-peptide measurements at room temperature for up to 24 hours without immediate centrifugation.

COMPARISON OF UNIVARIATE AND MULTIVARIATE REFERENCE INTERVAL METHODS

This paper compares univariate and multivariate reference interval methods, finding that multivariate approaches reduce false positives and improve accuracy in clinical settings.

Biobanking of Biological Samples at Room Temperature

The paper evaluates InstaPRESERVE as a room temperature storage solution for biospecimens, showing it preserves DNA, RNA, and protein quality comparable to frozen storage.

Freezing Diluted Bovine Serum Albumin Standards Does Not Significantly Affect Standard Curves

This study shows freezing diluted BSA standards at -20°C or -80°C and refreezing them up to three times does not significantly affect standard curves, making it a reliable method for protein quantification.

Lysosomal Enzyme activity: Establishing Reference Intervals from Patient Data

The paper establishes reference intervals for 15 lysosomal enzymes using 7851 patient samples across 17 assays.

Analytical validation of the PROphet test for treatment decision-making guidance in metastatic non-small cell lung cancer

This study validates the analytical performance of the PROphet test, a plasma proteomics-based tool for NSCLC treatment decisions, showing high precision and cross-platform consistency.

Genetic Sex Validation for Sample Tracking in Clinical Testing

The paper validates genetic sex using a 96-SNP PCR panel to track samples in clinical testing and identify inconsistencies.

Inadequate dried blood spot samples for Early Infant Diagnosis, how common and what are the reasons for rejection in Zimbabwe?

This study examines DBS sample rejection rates in Zimbabwe, finding 4% rejection with primary causes being insufficient volume and missing forms, and higher rejection rates at primary healthcare facilities.

Creating ethnicity-specific reference intervals for lab tests from EHR data

A novel method defines ethnicity-specific reference intervals for lab tests using EHR data, showing better prognostic value than existing intervals for serum creatinine and hemoglobin A1C.