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This study examines LAMA2 deficiency in mice, showing altered Schwann cell calcium homeostasis and increased nerve inflammation into adulthood.

This study investigates Arcellinida diversity in tropical peatlands, finding higher species richness in zones with developed understory vegetation and distinct community composition compared to extratropical ecosystems.

The paper develops computational algorithms to accurately estimate bacterial population growth rates using single-cell models and applies them to study antibiotic response heterogeneity and chemotaxis effects.

This study identifies a novel N-terminal region in TET1 that binds nucleosomes, enabling chromatin association in mouse embryonic stem cells through structural and biochemical validation.

The paper uses a multi-modal platform to profile single-cell stress responses in human cell lines, finding a shared stress response program with cell-specific magnitude variations.

The paper presents the first chromosome-scale reference genome for Mytilus planulatus, revealing structural variation and population structure in mussels.

This paper introduces an adjuvant (iCTA) that enhances in vivo CAR-T therapy against solid tumors by improving T-cell recruitment, antigen presentation, and tumor microenvironment.

This paper introduces a consensus framework for phylogenetic networks, demonstrating its effectiveness on simulated and real datasets.

This study shows CD19-CAR T-cell therapy depletes EBV+ autoreactive B cells and resets their repertoire, leading to sustained remission, while rituximab does not.

The paper develops a new transposon-induced model to identify cancer drivers in mice and shows similarities in driver landscapes between mice and humans.

MUTUAL enables cross-modality analysis between transcriptome and chromatin by learning a shared RNA-ATAC space from multiome data without refitting.

This study identifies polygenic trends in morning chronotype evolution in modern humans above 20 degrees north, showing increased morningness compared to Neanderthals.

This study shows GDF15 enhances NAD+ salvage and reduces immune response in mitochondrial disease by upregulating NMRK2 and modulating redox homeostasis.

This paper develops 3D printed EPR sample tubes with complex cross-sections to enhance signal sensitivity in aqueous samples, validated through simulations and experiments.

This study identifies a two-residue C-terminal truncation variant in AID causing adult-onset HIGM2 and shows it disrupts CSR and SHM.

The paper reanalyzes transcriptomic data to show that biochar exposure primes Formica japonica ants epigenetically, enhancing their resilience to environmental stressors.

This paper introduces a method to improve RNA-seq transcript quantification by reducing mapping ambiguity through minimal-shared region analysis, showing improved accuracy in isoform detection and abundance estimation.

The paper uses in-vivo MRI to measure noradrenergic and dopaminergic nuclei integrity in ADNI participants, finding these measures predict future cognitive decline and Alzheimer's progression.

This study evaluates the immunotoxic effects and metabolism of enniatins and beauvericin in human intestinal models, finding limited acute toxicity but distinct inflammatory responses and transport differences.