K. Green

A minimal two-residue C-terminal truncation of AID in adult-onset hyper-IgM syndrome type 2 (HIGM2)

This study identifies a two-residue C-terminal truncation variant in AID causing adult-onset HIGM2 and shows it disrupts CSR and SHM.

Antigenic determinants of HAstV-VA1 neutralization and their relevance in the human immune response

This paper identifies three neutralizing monoclonal antibodies against HAstV-VA1 and maps their epitopes, revealing four antigenic sites and immune pressure-driven mutations in a patient with encephalitis.

Camera-based monitoring of Bogong moths in Alpine Australia reveals drivers of migratory behaviour

This study uses camera-based monitoring to track Bogong moth migration patterns and identifies environmental factors influencing their behavior and population dynamics.

Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice

This study shows SARS-CoV-2 infects neurons in the CNS of K18-hACE2 mice, with microglia not restricting viral replication but contributing to inflammation.

Deep Learning Predicts Patterns of Cardiotoxicity in a High-Content Screen Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes

This paper uses deep learning and high-content screening of iPSC-derived cardiomyocytes to predict cardiotoxicity patterns in 1280 compounds and identify cardiotoxic chemical frameworks.

Epichloe festucae in mutualistic association with Lolium perenne suppresses host apoplastic cysteine protease activity

This study identifies and characterizes apoplastic cysteine proteases in Lolium perenne and shows that mutualistic Epichloe festucae suppresses their activity through potential inhibitors like LpCys1.

Poised cell circuits in human skin are activated in disease

The paper creates a single-cell atlas of human skin, showing how cell circuits change in inflammatory diseases like atopic dermatitis and psoriasis.

Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut.

This study shows that the probiotic E. coli Nissle 1917 uses yersiniabactin to acquire zinc in inflamed gut conditions, enhancing its colonization.

Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction

This paper describes a saliva-based SARS-CoV-2 testing method that avoids RNA extraction, achieving a detection limit comparable to nasal swabs and showing good performance with clinical samples.

Donor monocyte-derived macrophages promote human acute graft versus host disease

The paper identifies donor monocyte-derived macrophages as key players in human acute graft versus host disease, showing their enhanced activation of T cells and secretion of inflammatory cytokines.

A low-cost and high-precision scanning electrochemical microscope built with open source tools

The paper describes the construction of a low-cost, high-precision scanning electrochemical microscope using open source tools and tests it for biosensing applications.

Alleviation of Al toxicity by Si is associated with the formation of Al-Si complexes in root tissues of sorghum

This study shows that silicon alleviates aluminum toxicity in sorghum roots by forming Al-Si complexes in mucigel and outer apoplast, reducing Al binding to cell walls.