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This study investigates how intergenomic epistasis affects endpoint repeatability in coevolving species, finding high repeatability within landscapes but varying fitness outcomes across landscapes.

This study shows Aβ42 activates DDR2 in Alzheimer's disease models by non-canonically bypassing collagen ligands and promotes its nuclear enrichment, with structural insights into the mechanism and potential therapeutic inhibition.

This study maps the sequence preferences of the generalist class II lanthipeptide synthetase ProcM using mRNA display and machine learning, revealing moderate predictive accuracy compared to specialized enzymes.

This study identifies the olfactory organ in bobtail squid as a site for detecting and retaining symbiotic bacteria through cilia-driven vortices, distinct from the light organ.

This study shows the ER membrane protein complex (EMC) acts as a chaperone to facilitate the assembly of voltage-gated calcium channels during their biogenesis.

This study shows Guinea baboons adjust their space-use and foraging behavior in response to changes in food availability caused by a wildfire.

This study identifies SVEP1 as a mediator of ANG2-TIE1 binding, leading to TIE1 phosphorylation and downstream signaling in lymphatic endothelial cells.

CryoPilot uses two language model agents to automate cryo-EM structure determination, improving resolution and model accuracy through adaptive decision-making.

Four-model hiPSC screen in 384-well imaging reached 83% accuracy (88% sensitivity, 75% specificity) on 130 scored compounds from a 146-compound reference set, scalable to hundreds of compounds monthly.

This study maps chromothripsis in 1,646 human cancer cell lines, showing its conservation with tumors, higher prevalence, and therapeutic vulnerabilities to HDAC inhibitors.

The paper examines how ecotourism affects microbial diversity and water quality in a freshwater stream at Agua Azul Waterfalls, finding human-induced changes in physicochemical parameters and microbial communities.

GaussF improves isoform quantification by using a theoretical Gaussian model to correct sequencing biases without empirical data, outperforming existing tools.

This study tests asymbiotic germination of five Corybas species, finding limited germination and suggesting possible seed dormancy.

This study examines early transcriptomic responses to Toxoplasma gondii infection in pregnant sheep, identifying tissue-specific immune and stress pathways linked to fetal loss.

The paper investigates how inflammation alters cell type-specific glucocorticoid responsiveness through single-cell RNA sequencing in zebrafish.

This study quantifies nitrogen cycling in Arctic riparian zones, revealing active mineralization and denitrification despite low temperatures and organic carbon content.

The paper uses multimodal connectome data to identify patterns of functional and structural connectivity associated with disruptive behavior severity and change in youth.

The paper identifies Trps1 as a regulator of knee interzone formation through spatial comparisons and perturbation experiments in mice, showing its role in chondrogenic differentiation.

The paper examines associations between mPFC glutamatergic metabolites, redox balance, childhood maltreatment, and perceived stress in women with and without MDD.

This study develops three protocols to generate human iPSC-derived motor neurons with defined hindbrain, cervical, and lumbar identities, showing graded rostrocaudal specification and region-specific features.