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This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

This study identifies Pro3 as a key enzyme linking proline biosynthesis to cell wall integrity in Cryptococcus neoformans, showing its critical role in virulence and growth.

This study identifies N-glycosylation in Loxosceles venoms, revealing molecular heterogeneity and carbohydrate epitopes in toxins.

The paper presents a connection-level genetic atlas of human cortical functional connectivity, identifying genetic loci associated with resting and task states.

PatHoST reconstructs pathogen spatial distributions from host transcriptomes using weakly supervised learning, showing improved detection in both experimental and human SARS-CoV-2 data.

This study evaluates trityl and silyl ether analogs of andrographolide in murine cancer cell lines, finding potent anticancer activity and mechanisms involving apoptosis and Wnt1/β-catenin signaling.

The paper uses EM-based spatial connectomics to reveal the 3D structure of the mouse liver's sympathetic network, showing it is a meshwork with exposed varicosities and diverse cellular contacts.

The paper identifies a genetic maternal effect on microglia development through sox17 mutation in zebrafish, showing that maternal genotype impacts microglia and yolk sac precursor cells.

This study investigates behavioral indicators of welfare in Opilones by examining leg condition and response to aversive stimuli, finding fleeing and bobbing as potential negative welfare indicators.

The paper introduces ATLAS, a method to map transcriptional differences across genetic backgrounds in mouse brains, revealing significant cell type distribution changes between sexes and genetic models.

The paper investigates immune infiltration and triad formation in early melanoma progression using spatial transcriptomics, finding increased immune engagement in Stage I lesions compared to Stage 0.

PHENOMS analyzes hydrogen-bond networks in molecular dynamics simulations using Rust-accelerated code, achieving significant speedup over Python-based tools and demonstrating its utility with HDX-MS data.

The paper develops a pan-species ELISA for detecting heartwater antibodies in various mammals, showing high sensitivity and specificity across livestock, camels, and wildlife.

This study shows bumblebees retain multidimensional information about rewards in memory, preferring options that were better on multiple dimensions over those better on a single dimension.

This study uses MEG to investigate when and where modality-independent semantic representations emerge for images and words during encoding tasks.

This study shows influenza virus uses its nucleoprotein to block RIG-I activation by host RNAs, thereby suppressing the antiviral response and enhancing viral replication.

This study identifies a conserved Foxp1-Pde4d regulatory axis that preserves inflammatory responsiveness by controlling cAMP signaling across vertebrate species.

VoroTIDE segments protein domains using Voronoi contact areas and self-containment scores, achieving strong performance on benchmark datasets.