Dailin Gan

The paper identifies a genetic maternal effect on microglia development through sox17 mutation in zebrafish, showing that maternal genotype impacts microglia and yolk sac precursor cells.

The paper maps gene-by-gene-by-environment epistasis in cancer metastasis using CRISPR perturbations in mice, showing niche-dependent fitness and transcriptome convergence.

PAIR combines CRISPR activation and RNA knockdown to study bidirectional gene interactions in DNA repair, revealing strategies to enhance CRISPR-based gene editing precision.

This study evaluates LLM-derived gene embeddings for pathway information recovery using GSEA, showing they encode substantial biological knowledge.

The paper identifies an IL10 signaling axis that controls microglia lifespan through lysosomal dynamics in zebrafish and mouse models.

The paper identifies a Smad4-loss-driven neutrophil-enriched subtype in prostate cancer models and shows that targeting epigenetic enzymes can suppress tumor growth.

The paper evaluates open-source text-embedding models as alternatives to OpenAI's for gene analysis, finding some perform as well or better than OpenAI's models.

This study shows that combining ketogenic diet and HDAC inhibitors with ICB therapy enhances anti-tumor effects in prostate cancer by modulating epigenetic and immune mechanisms.

The paper introduces the GR2D2 estimator for precision matrices, showing superior performance in high-dimensional sparse settings and identifying cancer pathways in RNA-seq data.