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The paper reports cryo-EM structures of YsaN ATPase in dodecameric and tetradecameric states, revealing structural dynamics and mechanisms of oligomer assembly and function in the T3SS.

The paper analyzes AlphaFold's predicted binding pockets to determine their similarity to apo or holo states, finding most are holo-like and showing how state affects docking success.

This study shows that the A53E mutation in alpha-synuclein reduces aggregation and phosphorylation in vivo, leading to delayed progression of Parkinson's disease.

DUET is a sequence-only ensemble model for RNA-small molecule binding-site prediction that outperforms existing methods on benchmark datasets.

This study examines how cognitive-motor interactions develop from childhood to young adulthood using dual-task paradigms and mobile brain-body imaging, finding age-related changes in neural and motor responses.

The paper examines how bacterial and fungal biofilm communities respond to salinity gradients, finding distinct patterns in diversity and environmental drivers between the two groups.

The paper examines pre-stress functional brain connectivity in relation to anxiety during war-related stress and finds lower baseline connectivity between the right nucleus accumbens and right amygdala is linked to higher subsequent anxiety.

This study identifies McpA as a chemoreceptor in Salmonella Typhimurium that mediates taxis to oxygen and reactive oxygen species, revealing the CZB domain's role in redox sensing.

This study reports the cryo-EM structure of Pdr5, showing ergosterol binding and its effect on transporter activity, with implications for fungal drug resistance.

This study shows that livestock digestate ultrafiltrate supports higher microalgal biomass production than synthetic media and generates biostimulant biomass.

This study shows that flavonoids nobiletin and tangeretin restore circadian rhythms and improve sleep in mice with neuropathic pain.

Fox predicts host-symbiont co-evolution event rates directly from sequence alignments without tree reconstruction, achieving high accuracy and speed compared to existing methods.

This paper introduces MMRL, a framework for learning representations of somatic missense mutations across cancer types, showing improved prognostic discrimination and identification of mutation subtypes.

The paper uses computational methods to model structural and functional impacts of TPR domain deletions and amino acid substitutions in OGT linked to X-Linked Intellectual Disability.

This study shows goat milk-derived extracellular vesicles reduce glial inflammation in vitro and in vivo, modulating microglial activation and shifting the inflammatory profile towards resolution.

This study shows that polyploidy leads to reduced mitochondrial scaling and impaired metabolic function, with conserved effects across yeast and human cells.

CNVSIM creates a cross-study CNV reference atlas for cancer subtyping, identifying 112 subtypes across 19 cancer types using 155,881 neoplastic analyses.

The paper investigates how efference copy affects motion perception during smooth pursuit by analyzing perceptual and oculomotor responses to speed perturbations.

This paper introduces Duality vaccination, a method that delivers both activating and inhibitory stimuli to shape antibody responses, using nanoparticle-based immunogens.