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Dementia Severity Is Associated with Resting-State fMRI Network Responses to Nuisance Regression

The paper examines how dementia severity affects resting-state fMRI network responses to preprocessing, finding that greater severity correlates with reduced temporal concentration after nuisance regression.

Single-Cell Transcriptome-Wide Mendelian Randomization and Colocalization Analysis Reveals Immune Cell-Specific Mechanisms in Alzheimer's Disease

This paper uses single-cell eQTL-MR and colocalization analysis to identify immune cell-specific genetic mechanisms associated with Alzheimer's disease risk.

Robust T and B cell activation is associated with rapid clearance of infectious SARS-CoV-2

The paper identifies immune cell activation patterns associated with rapid clearance of infectious SARS-CoV-2 in both unvaccinated and vaccinated individuals.

Targeting NF-κB prevents Schwann cell reprogramming and plexiform neurofibroma initiation in mouse model of Nf1

Language-guided domain adaptation improves protein sequence rep-resentations for antimicrobial resistance analysis

BacLLM improves protein sequence representations for antimicrobial resistance analysis by integrating functional knowledge and enhancing resistance gene identification and mechanism prediction.

Compartment-Resolved Matrisome Shifts During Postnatal Tendon Maturation in Mice

This study uses compartment-resolved proteomics to analyze changes in the tendon matrisome during postnatal maturation in mice, revealing distinct trajectories in soluble and insoluble ECM components.

RNA-triggered Cas12a2 antibacterial activity and resistance plasmid degradation

This study demonstrates that an inducible CRISPR/Cas12a2 system can reduce bacterial growth and plasmid DNA in vitro and in vivo by targeting resistance transcripts.

Lipidic α-synuclein fibrils catalyze the formation of pathological mature fibrils

This study shows lipidic α-synuclein fibrils catalyze the formation of mature fibrils through a heterogeneous nucleation mechanism, lowering the energy barrier and following Ostwald's Rule of Stages.

Human lymphatic organoids reconstruct convergent developmental routes to functional lymphatic vessels

This study generates human lymphatic organoids from pluripotent stem cells using two mesodermal routes, showing they form functional vascular networks and support immune interactions.

Simple, static, spiking nonlinearities can account for seemingly complex interactions between visual, motor and cognitive variables in the visual cortex.

The paper shows that simple nonlinearities in the visual cortex can explain complex interactions between visual, motor, and cognitive variables through additive input modulation.

Clonally Convergent Tph/Tfh-like CD4+ T Cells are Shared Across Recovery and Recurrence in Experimental Periodontitis

The paper identifies clonally convergent Tfh/Tph-like CD4+ T cells that persist in the mucosa after recovery from periodontitis and contribute to recurrence.

A hawkmoth's point of view - Innate symmetry preferences are informed by floral display and foraging function in an insect pollinator

This study shows that hawkmoths have innate symmetry preferences influenced by floral display planes, which enhance foraging success.

memVar: an integrated resource for interpreting human membrane protein variation in molecular and disease contexts

memVar links human membrane protein variants to molecular contexts and disease, revealing enrichment of pathogenic variants in transmembrane regions and interaction sites.

Ferroptosis of selective progenitor cell types during embryogenesis ensures proper organ morphogenesis

This study identifies ferroptosis in embryonic lung and kidney progenitor cells, showing its role in organ morphogenesis through genetic manipulation of Gpx4.

Bayesian phylogenetic inference accounting for recombination in whole bacterial genomes

This paper introduces ClonalFrame2, a Bayesian method for phylogenetic inference in bacteria that accounts for recombination, showing improved accuracy in simulated and real datasets.

Regulation of Arabidopsis polyamine acetylation by NATA1 and NATA2

This study investigates the role of NATA1 and NATA2 in regulating polyamine acetylation in Arabidopsis, showing that NATA2 is heat-inducible and beneficial under heat stress, while its double knockout is lethal.

Sexual interactions and local selection shape reproductive gene diversity and divergence

The paper identifies genes under co-evolutionary selection in Drosophila melanogaster by analyzing nucleotide diversity and divergence patterns, finding links to sperm competition and mating behaviors.

Sex-specific gene and isoform expression characterizes hippocampal aging in rhesus macaques

This study identifies sex-specific gene and isoform expression changes in hippocampal aging of rhesus macaques and finds shared transcriptional signatures with Alzheimer's disease.

A Staphylococcus phage recombination cassette that enables recombineering across distant bacteria

The paper identifies a phage recombination cassette that enables recombineering across multiple bacterial species, including S. aureus, S. pyogenes, E. faecium, F. novicida, and E. coli.

T cell transcriptomes in simulated microgravity in vivo

This study examines how simulated microgravity affects T cell transcriptomes in humans, finding altered gene expression and inter-individual variability in response.