Matthew H. Spitzer

The paper identifies immune cell activation patterns associated with rapid clearance of infectious SARS-CoV-2 in both unvaccinated and vaccinated individuals.

This study engineers primary human T cells to deliver gene editing machinery using retroviral-based delivery vehicles, demonstrating efficient editing of diverse target cells.

This study shows that bNAb-mediated HIV suppression is linked to increased immune activation compared to ART suppression, with unique transcriptional patterns in controllers.

This paper develops a platform for longitudinal imaging and transcriptomics of live cells, revealing adaptive drug-resistant states and key drivers of cellular function through integrated analysis.

This study identifies T cell and macrophage subsets that mediate response to anti-PD-1 therapy in colorectal cancer, showing that combination therapy can eradicate tumors in both MMRd and MMRp settings.

This study identifies IL-6 as a driver of immunosuppression in glioblastoma, showing that its inhibition enhances response to immune checkpoint therapy and radiotherapy in preclinical models.

The paper identifies that TNFα secretion by tumor-infiltrating myeloid DCs is critical for CD8 T cell cytotoxicity, and shows that DC vaccines lose this function, limiting their efficacy.

The paper isolates and analyzes E. lenta genomes, revealing a distinct lineage associated with inflammation and highlighting its population structure and functional diversity.

The paper identifies coordinated variation between immune systems and microbiomes in healthy humans, linking it to tonic interferon states.

This study shows that commensal microbes in neonatal skin promote immune homeostasis by regulating monocyte accumulation and IL-17A production by T cells.

The paper uses single-cell proteomics and metabolomics to study how Ras pathway mutations affect hematopoiesis, finding distinct impacts on HSC compartments and metabolism.

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

This study identifies a biomarker, {beta}Alt, that predicts immune checkpoint blockade response in cold tumors by integrating TGF{beta} signaling, DNA repair, and immune context signatures.

The paper develops a mass cytometry method to track T cell receptor repertoires and differentiation states during infection and immunotherapy, showing how antigen recognition influences T cell responses.

This study shows that pretreating CAR-T cells with Metformin and Rapamycin improves their metabolic function and anti-glioma activity under hypoxic conditions in brain tumors.

SCITO-seq enables cost-effective profiling of over 10^5 cells using combinatorial indexing with dsc-seq, demonstrating feasibility in mixed cell lines and human lymphocytes.

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

MetaCyto enables meta-analysis of flow and mass cytometry data, revealing racial differences in immune cell populations across 2926 samples.