Discover, rate, and discuss biology preprints.

The paper reinterprets drug release kinetics in polymeric nanocapsules using a time-dependent effective potential barrier model, showing improved fit over WKB approximations and distinguishing between decay models.

The paper shows that TCR and IL2 receptor signaling synergize at the immunological synapse of CD8+ T cells, enhancing T-T synapse formation and function.

The paper examines how picocyanobacterial strains from different salinities adapt their growth and metabolism across varying salinity and light conditions.

This study investigates how LSD alters brain dynamics using MEG and machine learning, finding increased peak frequencies, reduced oscillatory power, and changes in spectral complexity.

This study evaluates tick-check stations as a surveillance tool, finding they provide comparable tick density estimates to active surveillance with lower effort in some scenarios and improve community knowledge about tick-borne diseases.

This study uses self-assembling nanoparticles to investigate how multivalent HA binding affects influenza virus interaction with glycan surfaces, finding that valency and receptor density significantly influence binding strength and mode.

The paper describes the implementation of a reproductive carrier screening program in Singapore, focusing on diverse Asian populations and highlighting community engagement and initial outcomes.

DyME enables high-throughput mutagenesis and molecular dynamics simulations to study protein recognition mimicry, providing tools for comparative analysis of mutational effects.

The paper shows human prostaglandin reductases PTGR1 and PTGR2 inactivate the antitubercular drug MCZ by dearomatizing it into H2MCZ, reducing its antimycobacterial activity.

This study shows lipid conjugates have different effects on cytosolic accumulation in E. coli and mammalian cells, highlighting context-dependent permeation strategies.

This study identifies region-specific lipid dysregulation in the cerebellum and cortex of Npc1-/- mice and myelin, revealing novel lipid alterations linked to NPC1 disease.

LOCOPOTS identifies stress-resilient potato genotypes using low-cost imaging and machine learning, revealing metabolic biomarkers for abiotic stress responses.

This study investigates the role of Klebsiella pneumoniae azoreductase in azo dye reduction, finding that its activity is lower than expected and suggesting non-enzymatic mechanisms may contribute to azo compound reduction in the gut.

This study shows that low-protein diets increase susceptibility to intestinal injury from DSS or C. rodentium in mice, with more severe symptoms and systemic inflammation.

The paper improves microbial production of diverse flavanones by evolving chalcone synthases using a biosensor-based screening approach.

The paper measures local nucleosome motion in living human cells during interphase and finds it remains nearly constant, with changes observed under specific perturbations.

This paper introduces NLG4, self-assembled nucleolipid G-quadruplexes that inhibit pancreatic cancer by targeting multiple oncogenes and pathways.

This study shows that N-acetylcysteine amide reduces stress behavior in zebrafish with a reactive coping style but not proactive, highlighting the role of antioxidant mechanisms in stress responses.

The paper shows that mitochondrial pyruvate transport and endocytosis regulate the cell jamming transition in epithelial tissues.