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Seasonal H1N1 influenza A virus preferentially infects a pre-existing ciliogenesis-primed secretory cell state

The paper identifies a ciliogenesis-primed secretory cell state preferentially infected by seasonal H1N1 IAV in human airway epithelium.

Integrating Microbial Ecology and Sustainability: Linking Agricultural Waste Gas Streams to Microbial Community Shifts in a Photobioreactor

This study examines microbial community dynamics in a photobioreactor using agricultural waste gas streams, showing spatially structured communities and partial nitrogen recovery.

Genomes of Solenogastres Shed Light on Ancestral Molluscan Biomineralization Genes

This study re-sequences Solenogastres genomes to analyze biomineralization gene evolution, finding reduced SMP gene families and structural proteins in Solenogastres compared to other molluscs.

PEEK: integrated primer design for silent-mutation and restriction-site engineering, validated in silico and by whole-plasmid sequencing

PEEK integrates silent-mutation and restriction-site engineering with accurate Tm calculations, validated by whole-plasmid sequencing.

Circulating CD4 regulatory T cells are broadly preserved in Parkinson's disease despite altered HELIOS expression

This study examines circulating CD4 regulatory T cells in Parkinson's disease and finds they are largely preserved in phenotype and function, though show reduced HELIOS expression in naive subsets.

Sensory experience-induced plasticity of somatostatin interneurons occurs through two-pore potassium (K2P) channels

The paper investigates experience-dependent plasticity in somatostatin interneurons and identifies two-pore potassium (K2P) channels as a mechanism underlying this plasticity.

HERACLES for fast and accurate likelihood-based reconstruction of massive lineages

HERACLES improves lineage reconstruction accuracy and scalability by optimizing cell coordinates in hyperbolic space using a composite likelihood model of CRISPR editing.

Pre-synaptic facilitation of corticospinal output improves dexterity and finemotor control after stroke

This study uses deep brain stimulation to enhance corticospinal output in monkeys with CST lesions, improving arm and hand function and fine motor control.

Bayesian Modeling of Context-Specific Goal-Directed and Habitual Control in Sequential Decision Making

This study investigates how context-specific habits and goal-directed planning interact in decision-making tasks, finding that sequence repetition aids stable performance but hinders adaptation to changes.

A Framework for Variant Filtering to Improve Diagnostic Outcomes in Genome Sequencing

This paper introduces a variant filtering framework called SMART filtering to improve diagnostic outcomes in genome sequencing by prioritizing non-coding and regulatory variants.

Genome assembly and characterization of two Brazilian soybean cultivars contrasting for stink bug resistance

The paper presents chromosome-level genome assemblies for two Brazilian soybean cultivars with contrasting stink bug resistance and identifies divergent gene isoforms between them.

An Accessible and Scalable Pipette-Driven Microfluidic Platform for Lipid Nanoparticle Formulation

This paper introduces a microfluidic platform for lipid nanoparticle formulation that improves scalability and efficiency in mRNA delivery.

Deep phenomics of African green monkey and Baboon PBMCs using a 30-marker spectral flow cytometry panel

The paper develops a 30-marker spectral flow cytometry panel to profile immune cell subsets in African green monkey and baboon PBMCs, focusing on T cell subsets, cytokines, and activation markers.

A largely shared genetic architecture underlies Saccharomyces cerevisiae persistence across different mouse host genotypes

This study shows that Saccharomyces cerevisiae persistence in mice is polygenic with strong additive effects and minimal host-genotype interactions.

Calibrating developmental dynamics from single-cell atlases: lineage paths outrun least-action routes

The paper introduces LADD to measure lineage path deviations from inferred developmental dynamics in single-cell RNA-seq data and finds lineages move faster than optimal paths.

Multi-Enzyme Data-Independent Acquisition Mass Spectrometry for Proteoform-Aware Single-shot Proteomics

The paper introduces mE-DIA, a multi-enzyme DIA-MS workflow that improves proteoform detection in proteomics by integrating analysis and interpretation into a single toolset.

Low-fidelity simulator selection for multi-fidelity inference of epithelial vertex models

The paper introduces PRISM to select low-fidelity simulators for multi-fidelity inference in vertex models, finding that early stopping is unreliable while coarser timesteps are effective.

Biocatalytic Asymmetric Radical Dearomatization of Electrophilic Heterocyclic and Non-Heterocyclic Arenes

This paper develops biocatalytic methods for asymmetric radical dearomatization of electrophilic arenes, achieving stereoselective transformations of challenging substrates.

Receptor-guided engineering of oncolytic vaccinia creates a synthetic support niche for off-the-shelf NK cell therapy

This paper develops a framework to engineer oncolytic vaccinia virus to support off-the-shelf NK cells by aligning viral payloads with NK cell manufacturing limitations.

Mapping the brain-web morphology to characterise ageing and cognitive impairment

This paper introduces SHARP, a method using cosmological web analysis to characterize brain ageing and cognitive impairment by analyzing MRI data from CamCAN and OASIS-3.