Joanne Jones

This study examines circulating CD4 regulatory T cells in Parkinson's disease and finds they are largely preserved in phenotype and function, though show reduced HELIOS expression in naive subsets.

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

The paper investigates TE transcription in Parkinson's disease brains, finding region- and cell-type-specific TE activation linked to an interferon response in microglia and neurons.

The paper identifies myelin basic protein (MBP) as an RNA chaperone that facilitates microglial nuclear import of myelin RNA, with implications for multiple sclerosis pathology.

dreampy implements the dreamlet framework for pseudobulk differential expression analysis in single-cell RNA-seq using Python.

TEsingle provides locus-specific transposable element expression analysis in single-cell data, revealing cell-type-specific TE expression in Parkinson's Disease.

The paper profiles immune cell RNA and protein expression across tissues and age to identify tissue-specific and age-related immune signatures.

FlowAtlas.jl connects FlowJo with Julia-based computational tools for cytometry data analysis, demonstrating its capabilities on a human immune cell dataset.

This paper introduces a 34-marker flow cytometry panel for comprehensive immunophenotyping of regulatory and effector lymphocytes in human samples.

The paper assesses the immunogenicity of RC17 hESC-derived dopaminergic neural progenitor cells, finding they are immunosuppressive and similar to fetal tissue, suggesting reduced need for aggressive immunosuppression post-transplantation.

The paper identifies CD8+FOXP3+ Tregs enriched in human tissues, expressing intracellular CD25 and tissue residency markers, and demonstrates their therapeutic potential and association with disease states.