Discover, rate, and discuss biology preprints.

The paper examines the balance between apoptosis and arrest-associated transcriptional programs in untreated PDAC, finding a consistent bias toward arrest programs.

The paper shows that during infection, Botrytis cinerea reallocates its transcriptome, altering synonymous codon demand across different host systems.

The paper describes a rare observation of a nocturnal arboreal kinkajou being followed by a puma in a rainforest canopy.

This paper introduces Zindex, a space-efficient indexing framework for large-scale sequence repositories, achieving compact storage and fast query performance with novel interleaved filters and merging mechanisms.

spearfish improves long-read mapping efficiency by leveraging transcriptome redundancy, achieving faster speeds and lower memory usage than existing tools.

This study examines the effects of isocaloric high-fat diet restriction with TAK-242 on metabolic and gut microbial responses in mice, finding limited normalization of adiposity and microbial community.

CausalODE infers gene regulatory networks from single-cell perturbation data by optimizing causal reach, capturing transient dynamics, and modeling latent protein levels, outperforming existing methods on real datasets.

This paper introduces SLAP2, a high-speed microscope for measuring submicron synapses and dendritic voltage in behaving mice, revealing nonlinear input-output amplification in neurons.

RPFace predicts RNA-protein interfaces directly from sequence, outperforming existing methods on RNA interfaces and generalizing to in vivo data without pretraining.

The paper identifies a novel epithelial cell type in zebrafish fins, spike cells, and shows their role in maintaining immune cell niche homeostasis through interactions with mpeg1+ immune cells.

The paper shows that mice retain spatial memory in the hippocampus after long absences, with neural patterns persisting despite changes in individual neuron activity.

The paper identifies oleate depletion as a metabolic signal sensed by C. elegans to activate innate immunity against bacterial infection.

This study examines energy flux changes in soil food webs during secondary succession, finding shifts from herbivory to detritivory and differences between plantation and natural forest types.

scCircaSim generates circadian single-cell and spatial transcriptomic data with known ground truth to evaluate analysis methods.

The paper evaluates contrastive learning on VOC-OR binding datasets, showing improved generalization and reduced performance inflation from identity leakage.

This study finds that a single session of mirror visual feedback does not significantly alter subsequent motor imagery-related neural activity.

The paper identifies aminopyridine compounds that target fungal group I introns, showing antifungal activity and synergy with amphotericin B.

This study uses pre-steady state kinetics and global data fitting to analyze CRL-dependent ubiquitylation, revealing kinetic parameters and catalytic efficiencies across different CRL systems and substrate contexts.

The paper uses a bio-realistic model of mouse primary visual cortex to show that cortical oscillations follow a spectrolaminar motif, with gamma in superficial layers and alpha/beta in deep layers, driven by specific cell types and synaptic properties.

The paper models cross-excitation in dorsal root ganglia to show it improves spatial localization at the cost of intensity encoding, leveraging the Weber-Fechner law.