Discover, rate, and discuss biology papers.

This study identifies an early physiologic calcification process in mouse tracheal cartilage and reveals MGP deficiency causes additional mucosal calcification, explaining respiratory symptoms in Keutel syndrome.

The paper identifies telotrons, telomeric repeat-containing introns, in multiple eukaryotic genomes and suggests telomerase drives intron creation and remodeling.

This paper identifies a TMEM175 mutation causing short QT syndrome and sudden cardiac death by disrupting lysosomal-mitochondrial interactions and impairing mitochondrial function.

The paper compares brain transcriptomes of social and solitary cichlid fishes to explore shared genetic mechanisms underlying social behavior evolution and plasticity.

This study investigates how the human brain encodes selected and non-selected visual targets during voluntary selection, finding that selected targets are encoded along an additional spatially selective axis.

This study characterizes the virome of the West Coast blackfly, identifying novel viruses and revealing geographic structuring in viral communities.

This paper introduces a fibrous optofluidic probe for measuring blood oxygenation and flow velocity in vessels, demonstrating its use in rabbit and canine models.

This study reports cryo-EM structures of the 50S ribosome with EngA-bound GTPγS or GDP, revealing conformational changes in EngA and a novel SLJ motif during ribosome assembly.

The paper investigates how lifestyle-associated microbiome shifts and host genetics influence gene expression in intestinal organoids, identifying microbiome-dependent allele-specific expression effects.

This study shows that systemic TLR7 agonism reduces disease severity in DSS-induced colitis in mice by shifting the immune response toward regulatory T cells.

The paper screens FDA-approved compounds to find mitophagy activators, identifying Meptazinol and Ponatinib as top candidates that increase mitolysosomes but do not rescue bioenergetic defects in mitochondrial diseases.

The paper compares three plasma proteomic metrics across organ systems to assess their associations with brain structure and neurodegenerative disease, finding distinct relationships and modest predictive value.

The paper expands and evaluates the PedMan system to manage peacock eye disease across olive cultivars with different susceptibility levels, achieving high accuracy in fungicide recommendations.

This paper introduces a deep learning framework for identifying dynamic protein allosteric sites across different conformational states, achieving improved performance over existing methods.

This study investigates how ADP and magnesium influence the structural changes and higher-order assembly of peroxiredoxin 2, showing distinct roles in disassembly and reassembly processes.

The paper shows Rab10 and Arhgef7 interact to link vesicle transport and exocytosis, promoting axon extension by facilitating PPV insertion into the plasma membrane.

The paper introduces ANA, an agentic AI framework that improves cross-site generalization in ASD fMRI classification by reducing data leakage and achieving higher accuracy than existing models.

This study shows that combining multiple low-dose inhibitors targeting the same oncogenic driver can delay drug resistance in cancer models.

This study compares viral replication and host responses in airway epithelial cells to distinguish pathogenic from seasonal coronaviruses, finding HCoV-229E induces severe epithelial injury despite limited replication.