F. Xu

Unbiased functional genetic screens reveal essential RNA modifications in human cancer and drug resistance

The paper identifies essential RNA modifications in cancer using CRISPR screens and finds that mitochondrial metabolic plasticity influences drug resistance through specific RNA modifications.

Design of PEG-based hydrogels as soft ionic conductors

This study designs PEG-based hydrogels with ionic conductivity by optimizing salt concentration, water content, and network structure to achieve desired mechanical and conductive properties.

TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry

This paper identifies TRIM32 as an intrinsic restriction factor against alphavirus infection, showing it inhibits viral genome translation through monoubiquitination and that disease mutants lose this antiviral activity.

Curved light sheet microscopy for centimeter-scale cleared tissues imaging

The paper introduces a curved light sheet microscope for high-throughput imaging of cleared tissues, achieving diffraction-limited resolution over a large field of view.

The Class III peroxidase OsPrx20 is a key regulator of stress response and growth in rice

This study identifies OsPrx20 as a key regulator of stress response and growth in rice, showing its dual role in osmotic stress tolerance and blast resistance.

Brain-wide neuronal circuit connectome of human glioblastoma

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

Long days induce adaptive secondary dormancy in seed of the Mediterranean plant Aethionema arabicum

This study shows that long-day light regimes induce secondary dormancy in Aethionema arabicum seeds, delaying germination to avoid risky summer conditions.

Electron-bifurcation and fluoride efflux systems in Acetobacterium spp. drive defluorination of perfluorinated unsaturated carboxylic acids

This study identifies electron-bifurcation and fluoride efflux systems in Acetobacterium spp. that enable reductive defluorination of PFAS, supported by biochemical and structural evidence.

The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration

This study compares transcriptomics, proteomics, and phosphoproteomics responses in HepG2 and AC16 cells to chemical exposure, finding phosphoproteomics changes occur earlier and at lower concentrations than transcriptomics.

Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

This study determines the structure of SCARF1 and identifies its ligand recognition mechanism, revealing key residues and shared binding sites for modified LDLs and bacterial teichoic acids.

Monocytes reprogrammed by 4-PBA potently contribute to the resolution of inflammation and atherosclerosis

This study shows that 4-PBA reprograms monocytes to resolve inflammation and atherosclerosis by altering adhesion and increasing anti-inflammatory markers.

Regulated Cleavage and Relocation of FERONIA Control Immunity in Arabidopsis Roots

Bacteria induce FER cleavage via At2-MMP to trigger localized immunity in Arabidopsis root transition/elongation zones.

Pneumatic Nano-Sieve for CRISPR-based Detection of Drug-resistant Bacteria

This paper introduces a nano-sieve device for MRSA purification and detection using CRISPR, achieving a 15x concentration factor and 100 CFU/mL LOD.

Circulating metabolites of Borneolum syntheticum (Bingpian) inhibit foam-cell formation in macrophages induced by oxidized low-density lipoprotein

A framework for Frizzled-G protein coupling and implications to the Wnt-PCP signaling pathways

This study presents cryo-EM structures of FZD6, FZD3, and FZD1 in active and inactive states, revealing a shared activation framework and potential crosstalk between G-protein binding and Wnt-PCP signaling.

Migratory herbivorous waterfowl track multiple resource waves during spring migration

This study shows East Asian herbivorous waterfowl use both seed and green waves during spring migration, with species-specific strategies depending on body size and location.

Inoviridae prophage and host dynamics during diversification, succession and Atlantic invasion of Pacific-native Vibrio parahaemolyticus.

This study investigates how Inoviridae prophages and host dynamics contributed to the diversification, succession, and Atlantic invasion of Vibrio parahaemolyticus lineage ST36.

Alternative splicing of its 5'-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

This study identifies alternative splicing of CD20 mRNA that generates translation-deficient isoforms, contributing to resistance to CD20-directed immunotherapies.

The soil emergence-related transcription factor PIF3 regulates root penetration by interacting with the receptor kinase FER

This study shows that PIF3, a transcription factor, regulates root penetration in Arabidopsis by interacting with FER, a receptor kinase, and modulating mechanosensitive ion channels and root cap cell sloughing.

Redistribution and activation of CD16brightCD56dim NK cell subset to fight against Omicron subvariant BA.2 after COVID-19 vaccination

This study shows that COVID-19 vaccination enhances the activation and redistribution of CD16brightCD56dim NK cells in Omicron BA.2-infected patients, improving clinical outcomes.

Oral Feeding of Nanoplastics reduces Brain function of Mice by Inducing Intestinal IL-1β-producing Macrophages

This study shows that oral nanoplastic exposure in mice leads to gut macrophage activation and IL-1β production, which affects brain function by causing microglial activation and cognitive decline.

Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

This study shows that MFN2 deficiency leads to increased cytosolic Ca2+ and overactivation of RhoA and non-muscle myosin II, causing atypical peripheral actin band formation in mouse embryonic fibroblasts.

Genome-scale mRNA transcriptomic insights into the mature growth dynamic of Cigar tobacco leaves

This study uses transcriptomic analysis to examine gene expression changes in cigar leaves at different growth stages, identifying key pathways and regulatory networks associated with maturity.

Wounding promotes root regeneration through a cell wall integrity sensor, the receptor kinase FERONIA

The paper identifies RALF33-FER as an early signaling module between wounding and root regeneration, interacting with TPL/TPRs to regulate regeneration-related genes.

TLR4/NF-κB Signaling Contributes to the Inflammation in Ovary and Inguinal Fats of Polycystic Ovary Syndrome

This study shows that TLR4/NF-κB signaling increases inflammation in ovarian and inguinal fat tissues of PCOS rats, worsening metabolic and reproductive symptoms.

Phytochromes mediate germination inhibition under red, far-red, and white light in Aethionema arabicum

The study identifies a phytochrome chromophore biosynthesis mutant in Aethionema arabicum, showing phytochromes mediate light inhibition of seed germination and influence plant morphology.

Using NAMs to characterize chemical bioactivity at the transcriptomic, proteomic and phosphoproteomic levels

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.

A Self-Healing, Viscoelastic Hydrogel Promotes Healing of Brain Lesions

This paper develops a self-healing hydrogel that mimics brain parenchyma viscoelasticity to promote healing of brain lesions in mice.

Subtyping evaluation of Salmonella Enteritidis using SNP and core genome MLST with nanopore reads

This study evaluates the use of nanopore sequencing for SNP and cgMLST subtyping of Salmonella Enteritidis, showing high concordance with Illumina data despite sequencing errors.

Biochemical characterization of Pectin Methylesterase Inhibitor 3 from Arabidopsis thaliana

This paper characterizes the biochemical activity of Arabidopsis thaliana PMEI3, showing its pH-dependent inhibition of PME activity and its effect on cell expansion.