Lifestyle-mediated shifts in the gut microbiome and host genetics modulate gene expression in intestinal organoids
Shreya Nirmalan, Sabrina Arif, Gabrielle Garlicki, Adnan Alazizi, Kaitlyn Hutchins, Mathilde Poyet, Mathieu Groussin, Peter Carbonetto, Roger Pique-Regi, Ran Blekhman, Francesca Luca
The paper investigates how lifestyle-associated microbiome shifts and host genetics influence gene expression in intestinal organoids, identifying microbiome-dependent allele-specific expression effects.
bioRxiv · Nov 10, 2026 · PreprintGenomics