Receptor binding domain (RBD) antibodies contribute more to SARS-CoV-2 neutralization when target cells express high levels of ACE2
A. G. Farrell, B. Dadonaite, A. J. Greaney, R. Eguia, A. N. Loes, N. M. Francko, J. Logue, J. M. Carreno, A. Abbad, H. Y. Chu, K. A. Matreyek, J. D. Bloom
This study shows that RBD antibodies contribute more to SARS-CoV-2 neutralization when target cells have high ACE2 expression, highlighting ACE2 levels as a critical experimental factor.
bioRxiv · Aug 29, 2022Immunology