Author

A. G. Farrell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:virus· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

B. Dadonaite· 3 shared J. D. Bloom· 3 shared H. Y. Chu· 2 shared J. Logue· 2 shared A. Abbad· 1 shared A. J. Greaney· 1 shared A. N. Loes· 1 shared B. Murrell· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersMicrobiology

B. Dadonaite

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 clades

B. Dadonaite, J. Brown, T. E. McMahon, A. G. Farrell, D. Asarnow, C. Stewart, J. Logue, B. Murrell, H. Y. Chu, D. Veesler, J. D. Bloom

This study uses deep mutational scanning to assess how mutations in SARS-CoV-2 spike proteins affect ACE2 binding, cell entry, and serum escape, linking these effects to clade growth rates.

bioRxiv · Nov 13, 2023Microbiology

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike

B. Dadonaite, K. H. Crawford, C. E. Radford, A. G. Farrell, T. C. Yu, W. W. Hannon, P. Zhou, R. Andrabi, D. R. Burton, L. Liu, D. D. Ho, R. A. Neher, J. D. Bloom

This paper introduces a pseudovirus system for deep mutational scanning of SARS-CoV-2 spike protein mutations, showing how they affect antibody neutralization and infection.

bioRxiv · Oct 13, 2022Microbiology

Receptor binding domain (RBD) antibodies contribute more to SARS-CoV-2 neutralization when target cells express high levels of ACE2

A. G. Farrell, B. Dadonaite, A. J. Greaney, R. Eguia, A. N. Loes, N. M. Francko, J. Logue, J. M. Carreno, A. Abbad, H. Y. Chu, K. A. Matreyek, J. D. Bloom

This study shows that RBD antibodies contribute more to SARS-CoV-2 neutralization when target cells have high ACE2 expression, highlighting ACE2 levels as a critical experimental factor.

bioRxiv · Aug 29, 2022Immunology