An evolutionary-based approach to quantify the genetic barrier to drug resistance in fast-evolving viruses: an application to HIV-1 subtypes and integrase inhibitors
K. Theys, P. Libin, K. van Laethem, A. Abecasis
The paper quantifies the genetic barrier to drug resistance in HIV-1 subtypes using an evolutionary-based method, identifying subtype-specific resistance mutations and codon usage differences.
bioRxiv · May 24, 2019Microbiology