Author

K. Theys

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Approach:benchmark study· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Abecasis· 2 shared P. Libin· 2 shared A. Feder· 1 shared A. Nowe· 1 shared A. Stern· 1 shared A.-C. Pineda-Pena· 1 shared A.-M. Vandamme· 1 shared K. van Laethem· 1 shared

Activity by Year

2016-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

A. Abecasis

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Author profile →

3 papers

Recent·Most cited

An evolutionary-based approach to quantify the genetic barrier to drug resistance in fast-evolving viruses: an application to HIV-1 subtypes and integrase inhibitors

K. Theys, P. Libin, K. van Laethem, A. Abecasis

The paper quantifies the genetic barrier to drug resistance in HIV-1 subtypes using an evolutionary-based method, identifying subtype-specific resistance mutations and codon usage differences.

bioRxiv · May 24, 2019Microbiology

The impact of HIV-1 within-host evolution on transmission dynamics

K. Theys, P. Libin, A.-C. Pineda-Pena, A. Nowe, A.-M. Vandamme, A. Abecasis

This paper reviews how HIV-1 within-host evolution affects transmission dynamics and disease progression by examining trade-offs between virulence and infectiousness.

bioRxiv · Dec 13, 2017Microbiology

Within-patient HIV mutation frequencies reveal fitness costs of CpG dinucleotides, drastic amino acid changes and G->A mutations

K. Theys, A. Feder, M. Gelbart, M. Hartl, A. Stern, P. S. Pennings

The paper estimates the fitness costs of 870 HIV mutations in vivo by analyzing mutation frequencies in the pol gene across 160 patients, finding higher costs for non-synonymous, drastic amino acid changes, and CpG-creating mutations.

bioRxiv · Jun 3, 2016Evolutionary Biology