Gene network modeling via TopNet reveals robust epistatic interactions between functionally diverse tumor critical mediator genes
H. R. McMurray, A. Ambeskovic, L. A. Newman, J. Aldersley, V. Balakrishnan, B. Smith, H. A. Stern, H. Land, M. N. McCall
The paper introduces TopNet, a gene network modeling method that identifies epistatic interactions among tumor critical mediator genes, revealing non-linear gene interactions and their role in cancer robustness.
bioRxiv · Oct 7, 2020 · PreprintCancer Biology