B. Smith

Operational lessons learned from simulating an elimination response to a transboundary animal disease in wild animals

The paper simulates a TAD control effort in wild pigs to identify operational challenges and propose solutions for rapid population reduction during a hypothetical outbreak.

Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology

This study evaluates the fitness and pathogenesis of Omicron variants in the upper and lower respiratory tracts, finding increased URT fitness with reduced lung pathology.

FosB/ΔFosB activation in mast cells regulates gene expression to modulate allergic inflammation in male mice

This study shows that FosB/ΔFosB in mast cells regulates gene expression to reduce allergic inflammation in male mice by enhancing DUSP4 expression.

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.

The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

A suite of selective pressures supports the maintenance of alleles of a Drosophila immune peptide

This study investigates the maintenance of diptericin A alleles in Drosophila by analyzing immune responses, sex-specific effects, and microbiome composition across different genotypes.

The AAA+ protein Msp1 recognizes substrates by a hydrophobic mismatch

This study develops a quantitative assay to show that Msp1 recognizes substrates via hydrophobic mismatch between the TMD and lipid bilayer.

Melanization of Candida auris is Associated with Alteration of Extracellular pH

This study identifies a novel mechanism of melanization in C. auris through extracellular alkalinization promoting non-enzymatic oxidation of L-DOPA to melanin.

Transcriptional profiles of a foliar fungal endophyte (Pestalotiopsis, Ascomycota) and its endohyphal bacterium (Luteibacter, Gammaproteobacteria) in co-culture support sulfur exchange and growth regulation

This study uses dual RNA-seq to compare gene expression of a foliar fungal endophyte and its endohyphal bacterium in co-culture and axenic conditions, revealing sulfur exchange and potential role of type VI secretion system in symbiosis.

Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina

This study investigates the pharmacokinetics and biodistribution of extracellular vesicles in macaques via intravenous and intranasal routes, finding longer plasma circulation times and organ uptake with IV administration, but limited systemic distribution with IN.

Immunogenicity of low dose prime-boost vaccination of mRNA vaccine CV07050101 in non-human primates

This study evaluates the immunogenicity of a low-dose prime-boost mRNA vaccine in non-human primates, finding limited antibody and T cell responses in some animals.

A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type virus and Delta variant

Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques

This study compares the pathogenicity of SARS-CoV-2 variants B.1.1.7 and B.1.351 in rhesus macaques, finding differences in clinical outcomes and immune responses.

A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitope

The paper identifies an antibody that neutralizes all SARS-CoV-2 variants by targeting a conserved epitope on the spike protein.

Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques

This study shows that T cell depletion in rhesus macaques does not cause severe SARS-CoV-2 disease but delays viral clearance, and T cells are not essential for immunological memory or protection against re-infection.

ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 1 disease

This study shows that the ChAdOx1 nCoV-19 vaccine protects Syrian hamsters from SARS-CoV-2 B.1.1.7 and B.1.351 variants, preventing weight loss, lung lesions, and viral replication.

Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis bioaerosols

This study develops a device to capture and detect live Mycobacterium tuberculosis in bioaerosols, showing high detection rates and suggesting aerosol sources differ from sputum.

Determining significant correlation between pairs of extant characters in a small parsimony framework

This paper introduces a method to assess significant correlations between pairs of traits across all most parsimonious evolutionary reconstructions using a phylogenetic tree.

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

This study shows intranasal ChAdOx1 nCoV-19 vaccination reduces SARS-CoV-2 shedding in animal models but not pneumonia protection.

Immunocompetent Mouse Model for Crimean-Congo Hemorrhagic Fever Virus

This paper develops an immunocompetent mouse model for CCHFV that replicates human disease severity, enabling better study of host-viral interactions.

Gene network modeling via TopNet reveals robust epistatic interactions between functionally diverse tumor critical mediator genes

The paper introduces TopNet, a gene network modeling method that identifies epistatic interactions among tumor critical mediator genes, revealing non-linear gene interactions and their role in cancer robustness.

Phosphodiesterase Type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins.

The paper shows Popeye domain-containing proteins form complexes with PDE4 phosphodiesterases in cardiac myocytes, restricting cAMP signaling and maintaining action potential duration.

Testing the predictability of morphological evolution in contrasting thermal environments

This study shows that morphological responses to temperature changes can be predictable in populations with limited gene flow, but less so when gene flow is present.

Characterization of extracellular vesicles and artificial nanoparticles with four orthogonal single-particle analysis platforms

This study compares four single-particle analysis platforms for sizing, counting, and phenotyping extracellular vesicles and synthetic particles, identifying differences in performance across modalities.

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine prevents SARS-CoV-2 infection and likely confers sterilizing immunity in mice.

Contemporary Enterovirus D68 strains show enhanced replication and translation at 37°C

This study shows contemporary EV-D68 strains replicate and translate more efficiently at 37°C compared to historic strains, suggesting increased pathogenicity.

The fate of carbon in a mature forest under carbon dioxide enrichment

This study tracks carbon fate in a mature forest under CO2 enrichment, finding that increased carbon uptake does not lead to greater sequestration, as most extra carbon is released via respiration.

A Moving Target: The Megaplasmid pMPPla107 Sensitizes Cells to an Inhibitory Agent Conserved Across Pseudomonas spp.

The paper shows that acquiring the megaplasmid pMPPla107 makes P. syringae strains more sensitive to an inhibitory agent produced by other Pseudomonas species.