Point mutations in topoisomerase I alter the mutation spectrum in E. coli and impact the emergence of drug resistance genotypes
A. Bachar, E. Itzhaki, S. Gleizer, M. Shamshoom, R. Milo, N. Antonovsky
This study shows that point mutations in topoisomerase I in E. coli alter mutation spectra, increasing tandem duplications and enhancing antibiotic resistance emergence.
bioRxiv · Apr 28, 2019Microbiology