Hematopoietic Stem Cells Undergo Differentiation State Reprogramming to Overcome Venetoclax Sensitivity in Patients with Myelodysplastic Syndromes
J. J. Rodriguez Sevilla, I. Ganan-Gomez, F. Ma, K. Chien, G. Montalban-Bravo, R. Kanagal-Shamanna, S. Loghavi, V. Adema, A. Bazinet, G. Garcia-Manero, S. Colla
This study shows MDS hematopoietic stem cells reprogram their differentiation state to bypass venetoclax sensitivity through genetic mutations and transcriptional changes.
bioRxiv · Sep 25, 2023 · PreprintCancer Biology