F. Ma

Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity

The paper identifies ZBP1 and mitochondrial Z-DNA as drivers of autoimmune photosensitivity through cGAS-STING activation in response to UVB.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Therapeutic Activity of Resolvin D1 (RvD1) in Murine MASH

This study investigates how RvD1 reduces inflammation, cell death, and fibrosis in MASH by targeting Stat1, ER stress, and MMP pathways.

Dysfunctional β-cell longevity in diabetes relies on high energy conservation and positive epistasis

The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.

White matter hyperintensity genetic risk factor TRIM47 regulates autophagy in brain endothelial cells

The paper identifies TRIM47 as a genetic risk factor for white matter hyperintensity and shows it inhibits autophagy in brain endothelial cells.

E-proteins set the threshold for optimal TCF1 expression during αβ T cell development.

This study shows E-proteins regulate TCF1 expression thresholds during T cell development, with EPE3 being critical for TCF1 levels and T cell differentiation.

IL-1B-mediated inflammatory signaling drives ineffective erythropoiesis in early-stage myelodysplastic syndromes

This study shows that IL-1B-mediated inflammation drives ineffective erythropoiesis in early-stage MDS and that canakinumab can reduce transfusion dependence in patients with DNMT3A and TET2 mutations.

Hematopoietic Stem Cells Undergo Differentiation State Reprogramming to Overcome Venetoclax Sensitivity in Patients with Myelodysplastic Syndromes

This study shows MDS hematopoietic stem cells reprogram their differentiation state to bypass venetoclax sensitivity through genetic mutations and transcriptional changes.

Cholesterol-associated Locus EHBP1 Protects against NASH Fibrosis

This study identifies EHBP1 as a protective locus against NASH fibrosis by regulating cholesterol metabolism and interacting with other cholesterol-related genes.

Targeting MCL1-driven anti-apoptotic pathways to overcome hypomethylating agent resistance in RAS-mutated chronic myelomonocytic leukemia

This study identifies MCL1 as a survival factor in RAS-mutated CMML, explaining resistance to BCL2 inhibitors and suggesting new therapeutic targets.

Targeting DNA2 Overcomes Metabolic Reprogramming in Multiple Myeloma

This study identifies DNA2 as a key factor in mitochondrial metabolism that enables multiple myeloma cells to survive DNA damage, showing that targeting DNA2 overcomes metabolic reprogramming and enhances therapy effectiveness.

STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity

This study shows that STAT3 is essential for maintaining hematopoietic stem cell function by suppressing interferon signaling and myeloid skewing, and its loss leads to impaired hematopoietic activity.

Vitamin C is an efficient natural product for prevention of SARS-CoV-2 infection by targeting ACE2 in both cell and in vivo mouse models

This paper shows that Vitamin C reduces ACE2 protein levels and blocks SARS-CoV-2 infection in cell and mouse models by inhibiting USP50-ACE2 interaction.

Transcriptional drifts associated with environmental changes in endothelial cells

The paper identifies transcriptional changes in endothelial cells due to environmental factors like shear stress and heterotypic interactions, showing their impact on gene expression independent of genetic background.

Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX

This study identifies UTX as a key X-linked epigenetic regulator causing sex differences in NK cell function, with males showing reduced IFN-γ production despite higher numbers.

Dynamic evolution of recently duplicated genes in Caenorhabditis elegans

This study examines the evolutionary dynamics of recently duplicated genes in C. elegans, finding they show rapid turnover, high diversity, and selection signals but are rarely essential.

Single cell transcriptomics reveals distinct effector profiles of infiltrating T cells in lupus skin and kidney

This study uses single-cell RNA sequencing to analyze T and NK cells in cutaneous lupus skin and kidney, revealing distinct effector profiles and activation states across tissues.

Intracellular Delivery of Antibodies for Selective Cell Signaling Interference

This paper demonstrates the use of cationic lipid nanoparticles to deliver engineered antibodies into cells, enabling selective disruption of intracellular signaling via pYSTAT3.

Non-lesional and Lesional Lupus Skin Share Inflammatory Phenotypes that Drive Activation of CD16+ Dendritic Cells

The paper compares non-lesional and lesional lupus skin to show they share inflammatory features that activate CD16+ dendritic cells.

Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythrocytes

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

PFKFB3 DEPLETION ACTIVATES β-CELL REPLICATION BY CELL COMPETITIVE CULLING OF COMPROMISED β-CELLS UNDER STRESS

This study shows that PFKFB3 depletion in β-cells under diabetogenic stress increases β-cell replication by removing damaged cells, improving β-cell function and mass.

Fine-tuning of SUMOylation modulates drought tolerance

This study shows that both increased and decreased SUMOylation enhance drought tolerance in apple by modulating MdDREB2A stability through SUMOylation and ubiquitination.

The intensity of the immune response to LPS and E. coli regulates the induction of preterm labor in Rhesus Macaques

This study shows that live E. coli induces stronger immune responses, including higher IL6 and prostaglandin levels, leading to preterm labor in Rhesus macaques compared to LPS.

Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas

The paper uses single cell and spatial transcriptomics to map the cellular architecture of antimicrobial responses in leprosy granulomas, identifying gene expression differences and spatial organization in reversal reactions.

Large genetic diversity and strong positive selection in F-box and GPCR genes among the wild isolates of Caenorhabditis elegans

This study identifies large genetic diversity and strong positive selection in F-box and chemosory GPCR genes across 330 C. elegans wild isolates, with significant divergence in non-Hawaiian populations.

Molecular mechanism of SARS-Cov-2 components caused ARDS in murine model

This study develops a non-infectious murine model to study SARS-CoV-2-induced ARDS and CSS, and identifies potential therapeutic agents that alleviate inflammatory symptoms.

Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing based molecular epidemiological study

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

Single-cell transcriptome profiling reveals neutrophil heterogeneity and orchestrated maturation during homeostasis and bacterial infection

This paper uses single-cell RNA sequencing to characterize neutrophil heterogeneity and maturation during homeostasis and bacterial infection, revealing distinct subsets and their functional transitions.

Highly Efficient, Massively-Parallel Single-Cell RNA-Seq Reveals Cellular States and Molecular Features of Human Skin Pathology

The paper introduces an improved scRNA-Seq protocol, Seq-Well S^3, which enhances transcript capture and gene detection efficiency, and applies it to study inflammatory skin diseases.