Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases
E. M. Da Costa, G. Armaos, G. McInnes, A. Beaudry, G. Moquin-Beaudry, V. Bertrand-Lehouillier, M. Caron, C. Richer, P. St-Onge, J. Johnson, N. Krogan, Y. Sai, M. Downey, M. Rafei, M. Boileau, , N. J. M. Raynal
This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.
bioRxiv · Dec 11, 2018 · PreprintPharmacology & Toxicology