Author

M. Downey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:yeast· 1

Frequent Co-Authors

A. Beaudry· 1 shared A. Denoncourt· 1 shared A. Haman· 1 shared C. Beausejour· 1 shared C. Richer· 1 shared D. Sinnett· 1 shared E. Flores-Diaz· 1 shared E. M. Da Costa· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Beaudry

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2 papers

Recent·Most cited

Ionic polyphosphorylation of histidine repeat proteins by inorganic polyphosphate

N. Neville, K. Lehotsky, Z. Yang, K. A. Klupt, A. Denoncourt, M. Downey, Z. Jia

The paper identifies 30 human and yeast histidine repeat proteins modified by inorganic polyphosphate, showing this modification disrupts phase separation and inhibits kinase and transcription factor activity.

bioRxiv · Apr 10, 2023Biochemistry

Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases

E. M. Da Costa, G. Armaos, G. McInnes, A. Beaudry, G. Moquin-Beaudry, V. Bertrand-Lehouillier, M. Caron, C. Richer, P. St-Onge, J. Johnson, N. Krogan, Y. Sai, M. Downey, M. Rafei, M. Boileau, , N. J. M. Raynal

This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.

bioRxiv · Dec 11, 2018 · PreprintPharmacology & Toxicology