The shared neoantigen landscape of MSI cancers reflects immunoediting during tumor evolution
A. Ballhausen, M. J. Przybilla, M. Jendrusch, S. Haupt, E. Pfaffendorf, M. Draxlbauer, F. Seidler, S. Krausert, A. Ahadova, M. S. Kalteis, D. Heid, J. Gebert, M. Bonsack, S. Schott, H. Bläker, , M. Kloor
The study identifies shared immunogenic neoantigens in MSI cancers and finds a negative correlation between indel mutation frequency and neoantigen immunogenicity, suggesting immunoediting during tumor evolution.
bioRxiv · Jul 16, 2019Cancer Biology