Author

M. Kloor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

M. von Knebel Doeberitz· 4 shared A. Ahadova· 3 shared S. Haupt· 3 shared V. Heuveline· 3 shared H. Bläker· 2 shared J. Gebert· 2 shared A. B. Riemer· 1 shared A. Ballhausen· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersCancer Biology

M. von Knebel Doeberitz

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4 papers

Recent·Most cited

A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis

S. Haupt, N. Gleim, A. Ahadova, H. Bläker, M. von Knebel Doeberitz, M. Kloor, V. Heuveline

This paper develops a computational model to simulate colonic crypt evolution in Lynch syndrome, showing the importance of stem cell dynamics and MMR deficiency in CRC development.

bioRxiv · Dec 29, 2020Cancer Biology

Pharmacological inhibition of nonsense-mediated RNA decay augments HLA class I-mediated presentation of neoepitopes in MSI CRC

J. P. Becker, D. Helm, M. Rettel, F. Stein, A. Hernandez-Sanchez, K. Urban, J. Gebert, M. Kloor, G. Neu-Yilik, M. von Knebel Doeberitz, M. W. Hentze, A. E. Kulozik

The paper shows that inhibiting nonsense-mediated RNA decay increases HLA class I presentation of neoepitopes from frameshift mutations in MSI colorectal cancer.

bioRxiv · Oct 13, 2020Cancer Biology

Mathematical Modeling of Multiple Pathways in Colorectal Carcinogenesis using Dynamical Systems with Kronecker Structure

S. Haupt, A. Zeilmann, A. Ahadova, M. von Knebel Doeberitz, M. Kloor, V. Heuveline

This paper develops a dynamical system model with Kronecker structure to simulate colorectal carcinogenesis pathways in Lynch syndrome, enabling mathematical analysis of tumor evolution and mutation dynamics.

bioRxiv · Aug 14, 2020Cancer Biology

The shared neoantigen landscape of MSI cancers reflects immunoediting during tumor evolution

A. Ballhausen, M. J. Przybilla, M. Jendrusch, S. Haupt, E. Pfaffendorf, M. Draxlbauer, F. Seidler, S. Krausert, A. Ahadova, M. S. Kalteis, D. Heid, J. Gebert, M. Bonsack, S. Schott, H. Bläker, , M. Kloor

The study identifies shared immunogenic neoantigens in MSI cancers and finds a negative correlation between indel mutation frequency and neoantigen immunogenicity, suggesting immunoediting during tumor evolution.

bioRxiv · Jul 16, 2019Cancer Biology