Cryptococcus neoformans secretes small molecules that inhibit IL-1β inflammasome-dependent secretion
P. H. Bürgel, C. L. Marina, P. H. V. Saavedra, P. Albuquerque, P. H. Holanda, R. d. A. Castro, H. Heyman, C. Coelho, R. J. B. Cordero, A. Casadevall, J. Nosanchuk, E. Nakayasu, R. C. May, A. H. Tavares, A. Bocca
This study shows that secreted molecules from Cryptococcus neoformans inhibit inflammasome-dependent macrophage responses, reducing antifungal activity and enhancing fungal survival.
bioRxiv · Feb 19, 2019Immunology