P. Albuquerque

Hinge Influences in Murine IgG Binding to Cryptococcus neoformans Capsule

This paper investigates how the constant region, specifically the hinge, influences antigen binding in murine IgG antibodies targeting Cryptococcus neoformans capsule polysaccharides, showing that the hinge is necessary but not sufficient for binding differences between isotypes.

Molecular mechanisms of LC3-associated phagocytosis in the macrophage response to Paracoccidioides spp.

This study investigates the role of LC3-associated phagocytosis in macrophage response to Paracoccidioides spp., finding that autophagy is important for antifungal activity and that signaling pathways differ from other fungi.

Paracoccidioides HSP90 can be found in the cell surface and is a target for antibodies with therapeutic potential

The paper generates a monoclonal antibody against HSP90 in Paracoccidioides fungi that opsonizes fungal cells and enhances macrophage uptake, suggesting potential for immunotherapy.

Faster Cryptococcus melanization increases virulence in experimental and human cryptococcosis

This study shows that faster melanization in Cryptococcus species correlates with increased virulence and worse patient outcomes.

A hidden battle in the dirt: soil amoebae interactions with Paracoccidioides spp

This study shows that soil amoebae interact with Paracoccidioides spp., increasing fungal virulence through the accumulation of cell wall alpha-glucans.

Cryptococcus neoformans secretes small molecules that inhibit IL-1β inflammasome-dependent secretion

This study shows that secreted molecules from Cryptococcus neoformans inhibit inflammasome-dependent macrophage responses, reducing antifungal activity and enhancing fungal survival.

Opsonin-free, real-time imaging of Cryptococcus neoformans capsule during budding

This study develops a method to observe Cryptococcus neoformans capsule dynamics in real-time without opsonins, revealing capsule distribution during budding.