Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes
A. Bochynska, A. T. Stenzel, R. Sayadi Boroujeni, C.-C. Kuo, M. Barsoum, W. Liang, P. Bussmann, I. G. Costa, J. Luscher-Firzlaff, B. Luscher
This study shows that loss of Ash2l in mouse fibroblasts reduces H3K4 methylation and gene expression, leading to senescence independent of SASP, with FoxM1-responsive genes involved.
bioRxiv · Feb 11, 2022Cell Biology