Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq
S. E. Vazquez, S. A. Mann, A. Bodansky, A. F. Kung, Z. Quandt, E. M. N. Ferre, N. Landegren, D. Eriksson, P. Bastard, S.-Y. Zhang, J. Liu, A. Mitchell, C. Mandel-Brehm, B. Miao, G. Sowa, , J. L. DeRisi
This paper scales PhIP-Seq for autoantibody discovery across multiple autoimmune diseases and COVID19, enabling machine learning predictions and identification of disease-specific autoantigens.
bioRxiv · Mar 23, 2022Immunology