A. Mitchell

Prefrontal brain-to-brain synchrony during human group hunting: Evidence from fNIRS hyperscanning

The paper examines brain-to-brain synchrony during group hunting using fNIRS hyperscanning and finds greater synchrony in prefrontal cortex regions during successful hunting.

Resistance Signatures Manifested in Early Drug Response in Cancer and Across Species

This study identifies early transcriptional signatures of drug resistance in cancer and across species, showing conservation and predictive value for treatment response.

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

This study shows FLT3 is essential for ITD-mutated leukemic stem cells but not for normal hematopoietic stem cells, supporting targeted therapies for AML.

Colibactin-induced damage in bacteria is cell contact independent

This study shows colibactin-induced DNA damage in bacteria occurs without cell contact, challenging previous assumptions about its delivery mechanism.

Morphometrics as a conservation tool for rapid in-situ distinction of native and introduced iguanas: comparing Iguana delicatissima and Iguana iguana

The paper identifies morphometric traits to distinguish native Iguana delicatissima from introduced green iguanas, enabling rapid in-situ conservation efforts.

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML

The paper constructs a reference atlas of human hematopoiesis and maps AML differentiation patterns, revealing genetic and non-genetic factors driving aberrant differentiation in leukemia.

KDM6A loss sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition

This study shows that KDM6A loss in AML increases sensitivity to PARP and BCL2 inhibitors, suggesting a new combination therapy approach for KDM6A-mutant AML.

Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq

This paper scales PhIP-Seq for autoantibody discovery across multiple autoimmune diseases and COVID19, enabling machine learning predictions and identification of disease-specific autoantigens.

A primary patient-derived model for investigating functional heterogeneity within the human Leukemic Stem Cell Compartment

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in AML

This study identifies a cellular hierarchy framework in AML that links disease heterogeneity with drug response and develops a 7-gene biomarker predictive of drug sensitivity.

Transposable Elements Shape Stemness in Normal and Leukemic Hematopoiesis

The paper identifies transposable elements (TEs) as genetic drivers of stemness in normal and leukemic hematopoiesis, showing their role in maintaining stem cell properties through chromatin accessibility.

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle

This paper identifies structural changes in a non-hemolytic pneumolysin variant that disable pore formation, enabling pneumococcus to adopt an intracellular lifestyle with reduced inflammation and increased host tolerance.

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

The paper quantifies mitochondrial features in purified human immune cell subtypes and mixed cell populations, revealing age- and sex-related differences and confounding effects of cell type distribution and platelets.

Unifying the known and unknown microbial coding sequence space

The paper presents a framework and workflow to integrate genes of unknown function into genomic analysis, quantifying their diversity and relevance across biomes and providing a resource for studying Cand. Patescibacteria.

An updated global COI barcode reference data set for Fall Armyworm (Spodoptera frugiperda) and first record of this species in Bhutan

The paper confirms the first detection of Fall Armyworm in Bhutan and presents an updated DNA barcode reference dataset for this species.

Cooperative foraging behavior during larval stage affects fitness in Drosophila

This study shows that cooperative foraging in Drosophila larvae delays development but increases adult fitness through larger wings.

A global perspective on microbial diversity in the terrestrial deep subsurface

This study analyzes microbial diversity in the terrestrial deep subsurface using 16S rRNA gene data, finding that aquifer lithology controls bacterial community diversity and identifying a core microbial consortium across different rock types.