Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5
S. J. Clasen, M. E. Bell, D. Lee, Z. Henseler, A. Borbon, J. de la Cuesta-Zuluaga, K. Parys, J. Zou, N. D. Youngblut, A. T. Gewirtz, Y. Belkhadir, R. E. Ley
The paper identifies a novel mechanism of TLR5 interaction with flagellins from gut commensal bacteria, termed silent recognition, which explains weak immune responses despite strong binding.
bioRxiv · Apr 12, 2022Microbiology