J. Zou

Transformer-based modeling of Clonal Selection and Expression Dynamics (TraCSED) reveals resistance signatures in breast cancer

TraCSED identifies resistance pathways in breast cancer by analyzing scRNA-seq data and clonal selection dynamics over time.

Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2

This study identifies DNMT3B as a promoter of colorectal cancer cell proliferation by inhibiting PLCG2 transcription through promoter methylation.

An interpretable integration model improving disease-free survival prediction for gastric cancer based on CT images and clinical parameters

This paper proposes a model integrating deep features, radiomics features, and clinical parameters to improve gastric cancer disease-free survival prediction, achieving a 3%-5% C-index and 10% AUC improvement.

Molecular basis for condensin enrichment at pericentromeres

This study identifies a molecular mechanism by which condensin is recruited to pericentromeres through a conserved interaction between Ycg1 and Sgo1, ensuring proper chromosome segregation.

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.

Single-cell transcriptome landscape of zebrafish liver reveals hepatocytes and immune cell interactions in understanding nonalcoholic fatty liver disease

The paper uses single-cell RNA sequencing to map zebrafish liver cell types and interactions, identifying macrophage subtypes and their role in nonalcoholic fatty liver disease.

The Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy

This study identifies RBX2 as a key component of the CRL5 ubiquitin ligase that regulates mitophagy in cardiomyocytes independently of PARKIN, maintaining cardiac homeostasis.

PLK1-Mediated Phosphorylation Cascade Activates the Mis18 Complex to Ensure Centromere Inheritance

The paper identifies PLK1-mediated phosphorylation of Mis18 and Mis18BP1 as essential for activating the Mis18 complex to ensure CENP-A loading and centromere inheritance.

A Murine Model of Post-acute Neurological Sequelae Following SARS-CoV-2 Variant Infection

This study uses a murine model to investigate persistent neurological symptoms after SARS-CoV-2 Delta variant infection, finding long-term immune activation and behavioral abnormalities.

The N-terminal region of DNMT3A combines multiple chromatin reading motifs to guide recruitment.

This study identifies the N-terminal region of DNMT3A as containing multiple chromatin-binding motifs that mediate recruitment through interactions with nucleosomes and ubiquitylated histone H2AK119.

Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1

This study compares the neutralization evasion of SARS-CoV-2 variants BA.2.86, XBB sublineages, and CH.1.1, finding BA.2.86 less evasive than XBB sublineages but CH.1.1 most evasive.

Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain

This study designs multimeric nanovaccines using icosahedral DNA origami to display SARS-CoV-2 RBD, showing enhanced B cell activation and immune responses in mice.

TMEM165 acts as a proton-activated Ca2+ importer in lysosomes

The paper identifies TMEM165 as a proton-activated Ca2+ importer in lysosomes, revealing a new mechanism for lysosomal Ca2+ refilling.

Disease-associated gut microbiome and metabolome changes in chronic low back pain patients with bone marrow lesions

This study examines gut microbiome and serum metabolome changes in chronic low back pain patients with bone marrow lesions, identifying key microbial species and metabolic pathways involved.

SMU_1361c regulates the oxidative stress response of Streptococcus mutans

This study identifies SMU_1361c as a transcriptional repressor regulating oxidative stress response in Streptococcus mutans, showing its role in pathogenesis and potential for therapeutic development.

Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

Leveraging medical Twitter to build a visual-language foundation model for pathology AI

The paper builds a visual-language foundation model for pathology AI using a large dataset of pathology images and natural language descriptions curated from medical Twitter.

Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease.

This study uses human organotypic epidermis to show that SERCA2 deficiency disrupts keratinocyte adhesion via ERK signaling, and identifies MEK inhibition as a potential therapy for Darier disease.

High Volume Rate 3-D Ultrasound Imaging Using Fast-Tilting and Redirecting Reflectors

This paper introduces a new 3-D ultrasound imaging technique called FASTER that improves volume rate and usability compared to conventional methods.

Modulation of WNT, Activin/Nodal and MAPK Signaling Pathways Increases Arterial Hemogenic Endothelium and Hematopoietic Stem/Progenitor Cell Formation During Human iPSC Differentiation

The impact of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids

This study evaluates how different extracellular matrix sources affect drug response and gene expression in pancreatic cancer organoids, finding no significant impact on pharmacotyping results.

Improved Neutralization of Omicron BA.4/5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent BA.4/5 Vaccine

This study compares the neutralizing antibody responses induced by monovalent and bivalent BA.4/5 vaccines against multiple Omicron sublineages in individuals over 55 years old, finding the bivalent vaccine elicits stronger neutralization.

Cross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages

This study examines the replication and cross-neutralization of SARS-CoV-2 Omicron sublineages in mice and human airway cultures, finding distinct antigenic profiles and bivalent vaccine support.

Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by 4 doses of parental mRNA vaccine or a BA.5-bivalent booster

This study evaluates the neutralization effectiveness of parental mRNA vaccines and BA.5-bivalent boosters against new SARS-CoV-2 variants, showing limited neutralization against BA.2.75.2, BQ.1.1, and XBB.1.

Stress vesicles are induced by acute mechanical force and precede the commitment of epidermal stem cells to terminal differentiation

This study shows that mechanical stress induces stress vesicles in epidermal stem cells, which are linked to cell fate and regulated by Piezo1 and calcium dynamics.

Transgressive and parental dominant gene expression and cytosine methylation during seed development in Brassica napus hybrids

The paper identifies transgressive and parental dominant gene expression and methylation patterns in Brassica napus hybrids during seed development, linking them to early heterosis mechanisms.

H3K36M provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis

This study shows that H3K36M oncohistone disrupts epithelial differentiation, increases cellular plasticity, and drives squamous carcinogenesis by altering histone modifications.

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

Neutralization of SARS-CoV-2 Omicron sublineages by 4 doses of mRNA vaccine

This study evaluates the neutralization of SARS-CoV-2 Omicron sublineages by different vaccination regimens and finds that 4-dose mRNA vaccines provide lower neutralization compared to 2-dose plus BA.1 infection.

Kynurenic acid promotes A1 to A2 astrocyte conversion against HIV-associated neurocognitive disorder

This study shows that kynurenic acid reduces A1 astrocyte activation and promotes A2 astrocyte formation, improving cognitive deficits in HIV-1 gp120 transgenic mice.