Direct RNA-binding by MYCN mediates feedback from RNA processing to transcription control
D. Papadopoulos, S. A. Ha, D. Fleischhauer, L. Uhl, K. Schneider, I. Mikicic, T. J. Russell, A. Brem, O. R. Valanju, P. Gallant, C. Schuelein-Voelk, H. M. Maric, P. Beli, G. Buechel, S. M. Vos, M. Eilers
This study shows MYCN binds RNA and regulates transcript turnover, with its RNA-binding activity affecting transcription control through competition with DNA-binding.
bioRxiv · Aug 16, 2023 · PreprintCancer Biology