K. Schneider

Direct RNA-binding by MYCN mediates feedback from RNA processing to transcription control

This study shows MYCN binds RNA and regulates transcript turnover, with its RNA-binding activity affecting transcription control through competition with DNA-binding.

Validation of polymorphic Gompertzian model of cancerthrough in vitro and in vivo data

This study validates the polymorphic Gompertzian model using in vitro and in vivo NSCLC data, showing it captures tumor dynamics and relapse trends better than classical models.

Mitochondrial protein import clogging as a mechanism of disease

The paper shows that mutations in mitochondrial preproteins cause clogging of the import pathway, leading to disease by impairing mitochondrial function and cell viability.

Female choice can explain the fertilization pattern in oaks

The paper tests a female choice hypothesis for oak fertilization patterns, showing that maternal diversity indices fit the model better than random ovule selection.

Is the Success of Adaptive Therapy in Metastatic Castrate Resistant Prostate Cancer Influenced by Cell-Type-Dependent Production of Prostate Specific Antigen?

This study evaluates how different cell-type contributions to PSA production affect the success of adaptive therapy in metastatic castrate-resistant prostate cancer.

Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture

This study develops a co-culture platform to study interactions between human colonic mucosal barriers and Faecalibacterium prausnitzii, showing anti-inflammatory effects and butyrate's role in modulating TLR3/4.

Impaired chloroplast positioning affects photosynthetic capacity and regulation of the central carbohydrate metabolism during cold acclimation

Cold acclimation has a differential effect on leaf vascular bundle structure and carbon export rates in natural Arabidopsis accessions originating from southern and northern Europe

The paper examines how cold acclimation affects leaf vascular bundle structure and carbon export rates in Arabidopsis accessions from southern and northern Europe, finding differential responses between the two groups.

Gut-Liver physiomimetics reveal paradoxical modulation of IBD-related inflammation by short-chain fatty acids

The paper uses human physiomimetic systems to show short-chain fatty acids can both improve and worsen ulcerative colitis depending on CD4 T cell activation state.

Massively parallel single-cell B-cell receptor sequencing enables rapid discovery of diverse antigen-reactive antibodies

The paper uses scBCR-seq to analyze B-cell repertoires and identifies antigen-reactive antibodies with high accuracy.

The metabolic response of Pseudomonas taiwanensis to NADH dehydrogenase deficiency

This paper investigates the metabolic response of Pseudomonas taiwanensis to NADH dehydrogenase deficiencies, finding high metabolic flexibility that enables phenotypic stability but complicates metabolic engineering.

Engineered reversal of function in glycolytic yeast promoters

The paper reverses the regulatory function of glycolytic yeast promoters to enable induction under glucose-poor conditions and validates their use for vanillin biosynthesis.