Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier
N. L. Tran, L. M. Ferreira, B. Alvarez-Moya, V. Buttiglione, B. Ferrini, P. Zordan, A. Monestiroli, C. Fagioli, E. Bezzecchi, G. M. Scotti, A. Esposito, R. Leone, C. Gnasso, A. Brendolan, L. G. Guidotti, G. Sitia
The paper shows that continuous IFNα infusion reduces CRC liver metastasis by acting on hepatic endothelial cells to create an antimetastatic vascular barrier.
bioRxiv · May 10, 2022Cancer Biology