Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes
C. Arenillas, J. Ruiz-Cantador, L. Celada, B. Calsina, E. Garcia-Galea, D. Datta, R. Fasani, A. B. Moreno-Cardenas, J. J. Alba-Linares, B. Miranda, A. M. Martinez-Montes, C. Alvarez Escola, B. Lecumberri, E. A. Gonzalez Garcia, S. K. Flores, , Rueda
This study links EPAS1HIF2 genetic adaptations in high-altitude populations to similar mutations in hypoxia-driven tumors, showing shared mechanisms in hypoxia response and tumorigenesis.
bioRxiv · Jun 10, 2024Cancer Biology