D. Datta

Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes

This study links EPAS1HIF2 genetic adaptations in high-altitude populations to similar mutations in hypoxia-driven tumors, showing shared mechanisms in hypoxia response and tumorigenesis.

Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis

This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.

Adaptation to ARF6-depletion in KRAS-driven PDAC is abolished by targeting TLR2

This study identifies TLR2 as a target to counteract adaptation to ARF6 depletion in KRAS-driven PDAC, reducing proliferation, migration, and invasion.

ACSL4 activity drives TNBC metastasis by positively regulating Histone H3 Acetylation mediated SNAIL expression

This study identifies ACSL4 as a driver of TNBC metastasis by enhancing histone acetylation and SNAIL expression through metabolic and epigenetic mechanisms.

Nucleo-cytoplasmic environment modulates spatio-temporal p53 phase separation

This study shows that p53 phase separation and condensate formation are modulated by the nucleo-cytoplasmic environment and cancer-associated mutations affect condensate stability and DNA binding.

Biocomposite Thermoplastic Polyurethanes Containing Evolved Bacterial Spores as Living Fillers to Facilitate Polymer Disintegration

This paper develops biocomposite thermoplastic polyurethanes containing heat-tolerant bacterial spores that enable polymer disintegration and retain programmed functions.

p53 amyloid pathology with cancer grades and p53 mutations

The paper shows p53 amyloid load correlates with cancer grades and shows both mutant and wild-type p53 form amyloids in cancer tissues.

PERK arm of UPR selectively regulates ferroptosis in colon cancer cells by modulating the expression of SLC7A11 (System Xc-)

This study shows that PERK inhibition reduces SLC7A11 expression and sensitizes colon cancer cells to ferroptosis, suggesting PERK inhibitors as potential therapeutics.

Toxic metal uptake by oyster mushrooms grown in sugarcane bagasse

This study investigates metal uptake by oyster mushrooms grown on sugarcane bagasse, finding biomagnification of heavy metals in mushrooms compared to the substrate.

Phenotypically Complex Living Materials Containing Engineered Cyanobacteria

This paper develops a 3D-printed biocomposite material containing engineered cyanobacteria that respond to chemical stimuli by producing functional outputs like bioremediation and inducible cell death.

Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer.

This paper shows that inhibiting MALAT1 increases sensitivity to PARP inhibitors in prostate cancer by impairing homologous recombination.

The BRD4S-LOXL2-MED1 interaction at the forefront of cell cycle transcriptional control in triple-negative breast cancer

This study shows that inhibiting LOXL2 and BRD4 together reduces triple-negative breast cancer proliferation by disrupting the BRD4S-LOXL2-MED1 interaction that controls cell cycle gene expression.

Liquid condensate is a common state of proteins and polypeptides at the regime of high intermolecular interactions

The paper demonstrates that proteins and polypeptides can form liquid condensates under high intermolecular interaction conditions, showing that LLPS is a common state across diverse molecular structures.

Possible Interference in Protein - Protein interaction as a new approach in microinhibition of respiratory pathogens on nasal- oral epithelium: An early on-screen study with reference toSARS-Cov-2-ACE2 binding interference

The paper investigates the interference of Lysine on protein-protein interactions and phospholipid bilayer behavior as a potential micro-inhibition strategy for respiratory pathogens on nasal/oral epithelium.

Co-aggregation and secondary nucleation in the life cycle of human prolactin/galanin functional amyloids

This study investigates co-aggregation and cross-seeding between prolactin and galanin in rat lactotrophs, revealing a novel mechanism of heterologous amyloid formation with implications for functional and pathological amyloids.

Dynamic modulation of spleen germinal center reactions by gut bacteria during Plasmodium infection

The paper shows gut bacteria dynamically influence spleen germinal center reactions and humoral immunity during Plasmodium infection, with effects dependent on baseline gut microbiota composition.

H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis

This study shows that H3K27me3 promotes TNBC peritoneal metastasis by upregulating KRT14 through repression of Sp1, and suggests tazemetostat as a potential therapeutic target.

Inhibition of Extracellular Vesicle-Associated MMP2 Abrogates Intercellular Transfer of Hepatic miR-122 to Tissue Macrophages and Curtails Liver Inflammation

The paper shows that inhibiting MMP2 on extracellular vesicles reduces miR-122 transfer to macrophages, thereby decreasing liver inflammation.

Amyloid fibril-based hydrogels for high-throughput tumor spheroid modeling

This paper develops amyloid fibril-based hydrogels for 3D tumor spheroid modeling, showing enhanced drug resistance and cancer biomarker expression compared to 2D cultures.

Salinomycin inhibits epigenetic modulator EZH2 to enhance Death Receptors in Colon Cancer Stem Cells

This study shows salinomycin inhibits EZH2 in colon CSCs, enhancing DR4/DR5 expression and reducing CSC traits, suggesting a therapeutic strategy combining TRAIL and EZH2 inhibitors.

CXCR4 intracellular protein regulates drug resistance and tumorigenic potential via modulating the expression of Death Receptor 5

The paper shows that intracellular CXCR4 protein, not its signaling, promotes drug resistance and tumorigenicity by downregulating DR5 through transcription factor modulation.