Coordinate transcriptional and post-transcriptional repression of pro-differentiation genes maintains intestinal stem cell identity
K. Buddika, Y.-T. Huang, I. S. Ariyapala, A. Butrum-Griffith, S. A. Norrell, A. M. OConnor, V. K. Patel, S. A. Rector, M. Slovan, M. Sokolowski, Y. Kato, A. Nakamura, N. S. Sokol
This study identifies P-body dependent repression of pro-differentiation genes in Drosophila intestinal stem cells, maintaining their identity by preventing inappropriate translation and expression of differentiation genes.
bioRxiv · Jun 27, 2020 · PreprintCell Biology