Drosophila

This study shows that sustained or transient SOX9 expression during axolotl limb development and regeneration leads to distinct cell fates and contributions to skeletal regeneration.

This study shows a dynamin mutation causes neuropathy-like phenotypes by affecting microtubule stabilization through Patronin/CAMSAP interaction in Drosophila and mammalian cells.

This study uses a Drosophila model to identify PRKX as a potential therapeutic target in bladder cancer by combining genotype-informed screening with human cell line validation.

This study shows that Synaptotagmin 7 regulates synaptic vesicle trafficking differently at tonic and phasic synapses in Drosophila.

This study identifies multiple Drosophila serpins with characteristics similar to human SERPINE1 using a multi-omics approach and comparative analysis.

The paper identifies a neural circuit in Drosophila that recognizes parasitoid wasps through visual features and drives defensive behaviors based on the wasp's position.

The paper introduces mechanical reporters to decode the global mechanical landscape during Drosophila gastrulation by analyzing cephalic furrow dynamics.

The paper manually traces and analyzes the tracheolar network in the adult Drosophila brain using electron microscopy data, revealing its structure and spatial relationship with neurons.

This study shows that C9orf72 repeat expansions cause presymptomatic lysosomal dysfunction in Drosophila, leading to DPR secretion and neurotoxicity, which can be mitigated by valproic acid.

This study identifies a high-order ion-coupling mechanism in EAAT transporters by showing that dEAAT2 can acquire Na+, H+, and K+ dependence through mutations, mimicking human hEAAT2's complex ion coupling.

The paper examines how Drosophila simulans adapts to three new transposable element invasions through piRNA cluster insertions and finds that resistance evolves independently in different strains.

This study shows that vitamin B3 supplementation protects mitochondria from antibiotic-induced damage, preserving bioenergetics and thermogenesis in Drosophila and human cells.

The paper shows that mesodermal FGF signaling stabilizes the ectoderm during dorsal closure in Drosophila, revealing a reciprocal influence between mesoderm and ectoderm.

The paper introduces PRISM to select low-fidelity simulators for multi-fidelity inference in vertex models, finding that early stopping is unreliable while coarser timesteps are effective.

This study identifies eIF4H1 as a conserved gene regulating sociality and neuronal development in Drosophila, supporting a genetic toolkit for social traits across species.

This study identifies extensive horizontal gene transfer in the fungus gnat Bradysia coprophila, showing these genes contribute to stress tolerance and ecological adaptation.

The paper clusters filopodia dynamics using functional data analysis to identify distinct temporal patterns linked to Notch signaling in fruit fly development.

The paper tests if mitochondrial backgrounds influence nuclear allele fate during hybridization, finding no evidence of such effects despite expected incompatibilities.

This study identifies an internal chemosensory system in Drosophila melanogaster's abdomen using Gustatory Receptors, revealing new roles in interoception beyond traditional feeding behaviors.

The paper investigates how gene expression influences genome-wide mutation rates in Drosophila melanogaster and Caenorhabditis elegans, finding that highly expressed genes have lower mutation rates due to transcription-coupled repair.

This study introduces SOPSim, a simulation tool that models sensory bristle patterning in fruit flies by incorporating filopodia dynamics and Notch signaling.

ORBIS reconstructs 3D tissue geometry from single-cell gene expression without spatial references, achieving lower shape error and faster sampling than existing methods.

This study shows that past adaptation to systemic infection affects the speed and mechanism of adaptation to oral infection in Drosophila, with sex-specific outcomes and trade-offs.

SNAzzy processes and analyzes high-throughput microscopy data from Drosophila embryos to study synchronous network activity.

The paper identifies differences in how two types of descending neurons in hoverflies encode visual information from small targets, revealing distinct pathways for target pursuit and threat detection.

The paper identifies genes under co-evolutionary selection in Drosophila melanogaster by analyzing nucleotide diversity and divergence patterns, finding links to sperm competition and mating behaviors.

The paper reconstructs the asperosaponin biosynthesis pathway in Dipsacus asperoides by integrating genomics, transcriptomics, and biochemical analyses, revealing gene family diversification and glycosylation order.

Earl Grey ParTEA annotates transposable elements across multiple genomes, revealing shared and private TE families and improving annotation consistency.

The paper develops workflows for targeted single-cell and single-nucleus RNA sequencing of rare neural populations in Tribolium castaneum using reporter and antibody-based enrichment strategies.

This study shows that PMCA interacts with Dlg to regulate presynaptic calcium levels in Drosophila NMJ, affecting neurotransmitter release and Ca2+ homeostasis.