Stabilization of the SARS-CoV-2 Receptor Binding Domain by Protein Core Redesign and Deep Mutational Scanning
A. C. Leonard, J. Weinstein, P. J. Steiner, A. Erbse, S. J. Fleishman, T. A. Whitehead
The paper stabilizes the SARS-CoV-2 RBD using deep mutational scanning and computational design, resulting in a more thermally stable and proteolytically resistant variant.
Protein Engineering, Design and Selection · Mar 24, 2022Peer-reviewedBiochemistry