Stromal cell sialylation suppresses T cells in inflammatory tumour microenvironments: A new tumour stromal cell immune checkpoint?
H. Egan, O. Treacy, K. Lynch, N. A. Leonard, G. O'Malley, K. DeVeirman, K. Vanderkerken, M. Craughwell, L. J. Egan, T. Ritter, A. M. Hogan, K. Redmond, M. Sheehan, A. Canney, S. Hynes, , A. E. Ryan
This study shows that sialylation of stromal cells in tumors enhances immunosuppression and that targeting this process can reverse immune cell exhaustion.
bioRxiv · Jun 18, 2021 · PreprintImmunology