Cell-specific crosstalk proteomics reveals cathepsin B signaling as a driver of glioblastoma malignancy near the subventricular zone
E. S. Norton, L. A. Whaley, V. K. Jones, M. M. Brooks, M. N. Russo, D. Morderer, E. Jessen, P. Schiapparelli, A. Ramos-Fresnedo, N. Zarco, A. Carrano, W. Rossoll, Y. W. Asmann, T. T. Lam, K. L. Chaichana, , H. Guerrero-Cazares
This study uses cell-specific proteomics to show that CTSB signaling from glioblastoma cells promotes malignancy by disrupting neurogenesis and inducing senescence in neural progenitor cells near the subventricular zone.
bioRxiv · Aug 19, 2023 · PreprintCancer Biology