Author

A. Chappleboim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

N. Friedman· 2 shared B. Mashahreh· 1 shared D. Joseph-Strauss· 1 shared K. E. Johansson· 1 shared K. Lindorff-Larsen· 1 shared O. Gershon· 1 shared R. Gardner· 1 shared R. Hartmann-Petersen· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

N. Friedman

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2 papers

Recent·Most cited

Conserved degronome features governing quality control-associated proteolysis

B. Mashahreh, S. Armony, K. E. Johansson, A. Chappleboim, N. Friedman, R. Gardner, R. Hartmann-Petersen, K. Lindorff-Larsen, T. Ravid

The paper identifies conserved degron features in yeast, viruses, and humans that govern quality control proteolysis, showing transmembrane domain-like sequences are key determinants of protein half-life.

bioRxiv · Apr 6, 2022 · PreprintCell Biology

Transcription feedback dynamics in the wake of cytoplasmic degradation shutdown

A. Chappleboim, D. Joseph-Strauss, O. Gershon, N. Friedman

This study investigates how cells adapt to Xrn1 depletion by monitoring mRNA and nascent mRNA dynamics, revealing a transcriptional response linked to cell cycle progression.

bioRxiv · Dec 1, 2021Cell Biology